18 / 30
allied
academies
Page 70
Note:
Journal of Gastronenterology and Digestive Diseases
|
Volume 3
J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d
GASTROENTEROLOGY
International Conference on
VON WILLEBRAND FACTOR AND PORTAL HYPERTENSION IN
CIRRHOTIC PATIENTS
Ehab Mostafa
Zagazig University, Egypt
P
ortal hypertension is associated with various hemodynamic changes not only in the portal circulation but in the systemic
circulation as well. These changes are related to several mediators secreted from endothelial cells. Von Willebrand factor
(vWF) is an endothelial derived coagulation factor and is believed to be involved in the pathogenesis of cirrhosis. This study aims
to clarify the relation between the vWF and the severity of liver disease and portal hypertension. 60 patients were included in
this study divided into three groups. Group I: 30 patients with decompensated cirrhosis. Group II: 20 patients with compensated
cirrhosis, group III: 10 healthy control subjects, the VWF level was highest in group I followed by group II then group III with
significant difference between all groups (114.2±27.5 in group I, 88.9 ± 9.1 in group II, and 65±3.9 in group III). The level of VWF
was correlated to ascites, encephalopathy, child’s grade and esophageal varices grade in group I. von Willebrand factor level rises
significantly with deterioration of liver disease and directly correlated to the grade of esophageal varices.
hobanoh@yahoo.comJ Gastroenterol Dig Dis 2018, Volume 3