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Journal of Gastronenterology and Digestive Diseases

Volume 3

J u n e 2 5 - 2 6 , 2 0 1 8 | D u b l i n , I r e l a n d

GASTROENTEROLOGY

International Conference on

THE HALLMARKS OF INFLAMMATORY BOWEL DISEASE -IBD

Susan A Joyce, Alvaro Lopez Gallardo, Julia Eickenberger, Adam Clooney, Cormac G Gahan, Car-

thage Moran, Marcus Claesson

and

Fergus Shanahan

University College Cork, Ireland

rritable bowel disease (IBD) includes Crohn’s disease (CD) and Ulcerative colitis (UC), both characterized by chronic relapsing

intestinal inflammation that leads to diminished quality of life, and during flare-up to severe disability. IBD is not a classic

autoimmune disease, IBD etiology is believed to be complex and multifactorial with genetics, the exposome (environment, diet,

lifestyle) the microbiome and the immune system interacting to manifest disease. Life style choices, the diet and metabolism

can influence disease status, we have applied a multivariate approach to analyze the same IBD disease cohort across the BMI

spectra, to include the microbiota, and microbially altered metabolites including precursors for bile acid synthesis, bile acids and

fatty acid signatures as well as some gut hormone and inflammation levels. Hallmarks of IBD that differentiate CD and UC have

been identified.

J Gastroenterol Dig Dis 2018, Volume 3