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Journal of Physical Therapy and Sports Medicine
Volume 1, Issue 1 Euro Physiotherapy 2017
Notes:
Page 57
December 07-08, 2017 Rome, Italy
4th Euro-Global Physiotherapy Congress 2017
Neuro-regenerative effect of autologous
mesenchymal stem cell therapy in cerebral
palsy patients: Clinical trial
Wael Abo El-Kheir1, Osama Ghannam 2, Esey El-Fiki3 and Hala Gabr4
1Military Medical Academy, Egypt
2Azhar University, Egypt
3Alexandria University, Egypt
4Cairo University, Egypt
Background: Stem cell-based therapies provide hope
for various CNS diseases including perinatal hypoxic
ischemic insults of the brain. Stem cells have the capacity
to proliferate in culture, migrate and disseminate following
implantation within the adult CNS. The neuroregenerative
potential of bone marrow-derived mesenchymal stem
cells (MSCs) is proposed to be through paracrine effect,
stimulation of endogenous stem cells, angiogenesis,
in addition to the disputed possibility of direct trans
differentiation.
Objectives: To study the impact of MSC transplantation
on psychomotor functions in patients with cerebral palsy.
Methods: Fifty two Egyptian patients with cerebral palsy
were divided into: group I (26 patients who underwent
autologous intrathecal bonemarrow-derivedmesenchymal
stem cell injection) and group II (26 patients who served
as control). Both groups were assessed, initially and after
one year, by a group of clinical scales to assess motor,
communication and independence skills.
Results: In group I, using Boyd’s developmental
progress scale revealed a statistically highly significant
improvement in motor, independence and communication
skills after SCT (P value<0.01). Also, 100 points scale
revealed a statistically significant improvement after SCT
(P value<0.05).
Conclusion: Autologous stem cell transplantation could
be a useful tool for the management of patients with
cerebral palsy as it may help in improvement of motor,
independence and communication skills.
Biography
Wael Abo El-Kheir is currently works as Professor of immunology &
Microbiology in military medical academy and he is the member of
the national committee for stem cells Egyptian ministry of health and also
honor as secretary of the Egyptian society of stem cells.
Wael Abo El-kheir et al., J Phys Ther Sports Med 2017