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Journal of Physical Therapy and Sports Medicine
Volume 1, Issue 1 Euro Physiotherapy 2017
Notes:
Page 54
December 07-08, 2017 Rome, Italy
4th Euro-Global Physiotherapy Congress 2017
Safety and efficacy of stem cell therapy in
ambulatory and non-ambulatory children
with duchene muscular dystrophy
Wael Abo El-Kheir1, Osama Ghannam 2, Esey El-Fiki3 and Hala Gabr4
1Military Medical Academy, Egypt
2Azhar University, Egypt
3Alexandria University, Egypt
4Cairo University, Egypt
Duchenne muscular dystrophy (DMD) is the most
common muscular dystrophy of childhood. This
incurable disease is characterized by muscle wasting
and loss of walking ability leading to complete wheelchair
dependence by 13 years of age. Prolongation of walking
is one of the major aims of treatment. This study is to
investigate the effects of allogenic mesenchymal stem
cell therapy in ambulatory and children with Duchene
Muscular Dystrophy and determine its suitability as a form
of treatment. This study was conducted on 35 myopathic
children 12 ambulatory, 10 non-ambulatory and 13
control (seven ambulatory and six on-ambulatory) aged
from 4-14 years. The control groups taken the traditional
treatment (physiotherapy and medical treatment drugs)
and the studied groups taken the same treatment
with allogenic bone marrow mesenchymal stem cells
intramuscular and systemic IV. Assesment was done by
North Star ambulatory assessment CHAQ (Child Health
Assessment Questionnaire) MRI/MRS Muscle Strength
Assessment -Myogrip, Myopinch, and Moviplate, manual
muscle strength testing using Medical Research Council
strength scores, functional outcome measures before and
after every three months for two years long and adverse
effect and complications inspected. There were significant
differences in assessment scores and quality of life
questionnaire between studied groups vs. control group.
There was minimal adverse effect and complications.
Biography
Wael Abo El-Kheir is currently works as Professor of immunology &
Microbiology in military medical academy and he is the member of
the national committee for stem cells Egyptian ministry of health and also
honor as secretary of the Egyptian society of stem cells.
Wael Abo El-kheir et al., J Phys Ther Sports Med 2017