euro-physiotherapy-2017-scientifictracks-abstracts

19 / 30

alliedacademies
Journal of Physical Therapy and Sports Medicine
Volume 1, Issue 1 Euro Physiotherapy 2017
Notes:
Page 48
December 07-08, 2017 Rome, Italy
4th Euro-Global Physiotherapy Congress 2017
Immune responses following McKenzie
lumbar spine exercise in individuals with
acute low back pain: A preliminary study
Saud Al-Obaidi and Fadia Mahmood
Kuwait University, Kuwait
Background: The pathophysiology of low back pain
(LBP) and disk-related sciatica is not limited to mechanical
compression of the neural tissue. Inflammation and
inflammatory mediators, has been implicated in the
production of acute or chronic pain.
Objectives: This study explores the immune responses
following 4 weeks of McKenzie lumbar spine exercise in
individuals with acute low back pain (ALBP).
Methods: Participants were 15 volunteered patients
with ALBP. Ten ml of peripheral blood were obtained
from each patient before and after 4 weeks of McKenzie
exercise intervention. All patients underwent subjective
and objective assessment. Intervention was custom
designed following McKenzie assessment and treatment
protocol. For a reference purpose similar blood samples
was obtained from 15 healthy individuals. Flow cytometric
analysis was used to evaluate the frequencies of CD4+ T
lymphocyte sub-populations and the intracellular cytokine
expression within this cell population. Pain perceptions
were obtained at baseline and following each week of
exercise sessions.
Results: There was no significant difference in the
frequency of T lymphocyte sub-populations; memory
(CD4+CD45RO+) T cells, helper inducer (CD4+CD29+)
T cells, CD3+CD16+CD56+ T cells and naive/suppressor
(CD4+CD45RA+) T cells at base line relative to these cell
populations after exercise sessions. Pain was significantly
reduced after 4 weeks of McKenzie exercise interventions
(p<0.05). The percentage of T cells expressing pro
inflammatory cytokines IL-8 and TNF-α and anti-
inflammatory cytokine IL-4 increased significantly (p<0.05)
following intervention. Interestingly, the reduction in pain
scores did not correlate with elevated anti-inflammatory
cytokines.
Conclusion: McKenzie exercise induced an immune
activation state and simultaneously up regulated anti-
inflammatory IL-4 cytokines that boost pain relief.
Biography
Prof. Saud received his Master degree in Physical Therapy from Washington
University at Sant louis Missouri in 1987, and his Ph.D. fromNewYork University
in 1991. Prof. Saud have over 30 years of clinical experience, in clinical
management of pain and musculoskeletal conditions and the subsequent
movement dysfunction. Professor Saud research areas include analysis of
abnormal movement management of acute and chronic pain and dysfunction,
focusing on the consequences of selected biopsychosocial factors including;
anticipation and fear of pain, exaggerated pain perception, pain avoidance
behavior, and related impact on physical performances. Recently he got
interested in immune responses following low intensity exercise performances
on pain modulation and immune process. Prof. Saud have published many
articles in prestigious international journal and served as a reviewer for many
local and international journal including ; Journal of Physical Therapy Theory
and Practice, Annals of Human Biology, Physiotherapy Research International,
Clinics and Practice, International Journal of General Medicine, Kuwait Medical
Journal, and Saudi Medical Journal. Professor Saud have developed and
patented 2 devices in his field of practice. Since 2007 Professor Saud works
as the Dean of Faculty of Allied Health Sciences, at Kuwait university.
Saud Al-Obaidi et al., J Phys Ther Sports Med 2017