ethnopharmacology-physiotherapy-congress-2019-tracks

18 / 19

Note:
Ethnopharmacology 2019
& Physiotherapy Congress 2019
Asian Journal of Biomedical and Pharmaceutical Sciences
ISSN: 2249-622X | Volume 9
Page 43
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
March 27-28, 2019 | Amsterdam, Netherlands
&
PHARMACOLOGY AND ETHNOPHARMACOLOGY
7th International Conference and Exhibition on
5th GLOBAL PHYSIOTHERAPY, PHYSICAL
REHABILITATION AND SPORTS MEDICINE
Joint Event on
PHYTOCHEMICAL PROFILE AND BIOLOGICAL PROPERTIES OF PISTACIA
VERA L HULL ESSENTIAL OIL
Antonella Smeriglio
University of Messina, Italy
Although the chemical composition and biological properties of some species of the genus Pistacia has
been investigated, studies on hull essential oil of Pistacia vera L variety Bronte (HEO) are currently lacking.
In this work, we have carried out an in-depth phytochemical profile elucidation by Gas Chromatography-Flame
ionization and Mass Spectrometry (GC-FID and GC-MS) analysis, and an evaluation of antioxidant scavenging
properties, using several in vitro methods, and checking its cytoprotective potential on lymphocytes treated
with tert-butyl hydroperoxide. Moreover, the antimicrobial activity against standard and clinical Gram-positive
and Gram-negative as well as Candida sp. strains, was also investigated. Quali-quantitative analysis highlighted
the richness of this complex matrix, with the identification of 40 derivatives. The major components identified
were 4-Carene (31.743%), α-Pinene (23.584%), D-Limonene (8.002%), and 3-Carene (7.731%). The HEO showed
a strong iron chelating activity and was found to be markedly active against hydroxyl radical. Moreover, HEO
pre-treatment increase significantly the cell viability, decreasing the lactate dehydrogenase (LDH) release. HEO
was bactericidal against all the tested strains at the concentration of 7.11 mg/mL, with the exception of Pseu-
domonas aeruginosa ATCC 9027, and fungicidal at concentrations between 2.50 and 5.0 mg/ml. The obtained
results demonstrate the strong free-radical scavenging activity of HEO along with remarkable cytoprotective
and antimicrobial properties, which makes the HEO potentially useful, particularly, in the treatment of fungal
infections, especially drug-resistant ones.
Antonella Smeriglio, Asian J Biomed Pharmaceut Sci 2019, Volume 9 | DOI: 10.4066/2249-622X-C1-017
Antonella Smeriglio is a research fellow in pharmacognosy at the department of chemical, biological, pharmaceutical
and environmental sciences of the University of Messina, Italy. She has master’s degree in pharmacy, PhD in toxicology
and specialized in pharmacognosy.
BIOGRAPHY