ethnopharmacology-physiotherapy-congress-2019-tracks

Note:

Ethnopharmacology 2019

& Physiotherapy Congress 2019

Asian Journal of Biomedical and Pharmaceutical Sciences

ISSN: 2249-622X | Volume 9

Page 34

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

March 27-28, 2019 | Amsterdam, Netherlands

PHARMACOLOGY AND ETHNOPHARMACOLOGY

International Conference and Exhibition on

GLOBAL PHYSIOTHERAPY, PHYSICAL

REHABILITATION AND SPORTS MEDICINE

Joint Event on

PROTECTIVE PROPERTIES OF SILYMARIN AGAINST THE TOXIC EFFECTS OF

VALPROIC ACID IN THE HEART

Ibrahim Aktas

and

Meltem Ozgocmen

Adiyaman University, Turkey

Suleyman Demirel University, Turkey

he aim of this study was to investigate the protective effect of silymarin against the effects of valproic acid

(VPA) in the heart of rats, which is used as a common antiepileptic in the treatment of epilepsy. VPA is a

substance consisting of an eight-carbon fatty acid called dipropylacetate for the treatment of epilepsy. It is

used in both parsiel and generalized epilepsy because it is effective in many seizures such as myoclonic, atonic,

absorptive, tonic and tonic-clonic. Moreover, exposure toVPA has been shown to induce cardiac malformations

in rats. It, due to its similarity to GABA, an inhibitor amino acid, inhibits GABA transaminase and reduces GABA

withdraw from the presynaptic junction by increasing the amount of GABA in the synaptic junction. Silymarin

is known to have a positive inotropic effect on the perfused adult rat heart. For 14 days, rats were divided into

3 groups as placebo control, VPA, VPA+silymarin. The group were given 500 mg/kg/day from VPA or/and 100

mg/kg/day from silymarin for 14 days, except placebo control group. At 15 day, all animals were sacrificed after

blood samples collected to assay of biochemical parameters such as glucose, albumin, amylase, bilirubin, calci-

um, total cholesterol, creatinine and triglyceride. All statistical analyzes were calculated by S.E.M ± in the graph-

pad prism program and p <0.05 was found to be statistically significant. Total chlosterol, albumin, amylase and

creatinine count significantly increased in the VPA+silymarin group but in the VPA group it’s count statistically

decreased compared to placebo group.

Ibrahim Aktas et al., Asian J Biomed Pharmaceut Sci 2019, Volume 9 | DOI: 10.4066/2249-622X-C1-017

Ibrahim Aktas has completed his PhD from Ankara University, Turkey. He has three publications, his study is about

pharmacokinetic, anti-anelgesic, assay of biochemical parameters and doxorubicin. He has been working since 2017

at Adiyaman University.

BIOGRAPHY