ethnopharmacology-physiotherapy-congress-2019-tracks

Note:

Ethnopharmacology 2019

& Physiotherapy Congress 2019

Asian Journal of Biomedical and Pharmaceutical Sciences

ISSN: 2249-622X | Volume 9

Page 33

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

March 27-28, 2019 | Amsterdam, Netherlands

PHARMACOLOGY AND ETHNOPHARMACOLOGY

International Conference and Exhibition on

GLOBAL PHYSIOTHERAPY, PHYSICAL

REHABILITATION AND SPORTS MEDICINE

Joint Event on

THE EFFECT OF SYNTHETIC CB2 RECEPTOR AGONIST (AM1241) ON CYTO-

KINE LEVELS IN OVALBUMIN-INDUCED ASTHMA IN RATS

Ali Parlar

University of Adiyaman, Turkey

sthma is a disease characterized by spontaneous contraction of the airways in response to a wide variety

of endogenous and exogenous stimuli, affecting approximately 300 million people worldwide and about

20% of the population in developed countries. Cannabinoids are compounds that have been used for many

years due to their medical properties and are involved in the regulation of the immune response, such as the

release of cytokines. The aim of this study was to explore the healing effect of cannabinoids on anti-inflamma-

tory. For 22 days, rats were divided into 5 groups as saline control, Ovalbumin (OVA), CB2 agonist (OVAA), CB2

agonist and antagonist (OVAA+A) and Vehicle (DMSO). Saline control group is used to set off asthma, all group,

but saline control, were given 100 mg of aluminum hydroxide in 0.9% sterile saline with 1 mg/kg ovalbumin

daily intraperitoneally for 3 days. All animals in the other groups, except for the animals in the saline control

group on same periods days of the experiment, received 0.8 m3 challenged for 20 minutes daily by inhalation

with a 1%OVA whole-body nebulizer. On 22

day pulmonary function tests were performed before all animals

were sacrificed. In the present study, some parameters such as cytokine levels were measured. Total WBC count

significantly increased in the OVA group but in the OVAA group it’s counts statistically decreased compared to

OVAA+A group. While GSH level in the OVA group measured to decrease compared to saline control and OVAA

groups, it’s level in the OVA group statistically insignificant compared to OVAA+A group.

Ali Parlar, Asian J Biomed Pharmaceut Sci 2019, Volume 9 | DOI: 10.4066/2249-622X-C1-017

Ali Parlar has completed his PhD from Ankara University, Turkey. He is working as an assistant professor in department

of pharmacology, medical faculty. He has 4 publications and his publication SCI-Expanded is 1 and has been serving as

an editorial board member of reputed journals.

BIOGRAPHY