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Journal of Clinical and Experimental Toxicology | Volume: 3
February 21-22, 2019 | Paris, France
International Conference on
Environmental Toxicology and Pharmacology
Notes:
J Clin Exp Tox, Volume 3
DOI: 10.4066/2630-4570-C1-006
Reducing toxicity by designing bio-inspired Nanomaterials
Monica Neagu
University of Bucharest, Romania
A
bove and beyond the nanoparticles that arise in the
environment, in nanomedicine, the toxicity displayed
by nanomaterials is a major concern. While developing new
nano-carriers and nano-drugs that have shown their medical
applications, research has witnessed new areas of toxicity
inflicted upon humans. Penetrating this domain, the search
has begun for finding the best option to overcome the known
toxicity of nanomaterials. In this view, a new domain has
been recently raising, the area of bio-inspired nanomaterials.
Nature has inspired nanomedicine to use materials that
reproduce the complexity of biomolecules mimicking the
functional characteristics. Resembling nature, various types
of functional nanosystems are explored. Thus, the area is
very broad, namely carbohydrates can be tailored to develop
nano-sensors, then peptides and proteins can be designed in
specific transporters of drugs through cells overcoming toxicity
and drug-resistance. The most recent bio-inspired endeavor
is designing entire synthetic viruses and bacteria that are the
perfect drug and active biomolecules carriers. The main groups
of biomolecules that can be developed in nanomaterials are
peptides, these structures having multiple chemical binding
capacities to be tailored in larger structures like proteins and/
or other biological molecules. Moreover, as nature has planned,
these biomolecules can respond to the biological milieu by
physiologically altering its structure and function; this property
suits very well their applications in nanomedicine. There are
several clear applications of bio-inspired nanomaterials like
reversing multi-drug resistance in cancer cells. In another
medical application, they can act as vaccine delivery systems.
Lipid-based particles, micelles, nanostructures of natural or
syntheticpolymers, andeven lipid-polymerhybridnanoparticles
can significantly increase vaccines immunogenicity. These
bio-inspired nanomaterials are still an open area that is to be
explored in the permanent scientific quest to reduce toxicity
while developing the best/efficient therapy accomplishment.
e:
neagu.monica@gmail.com