envipharm-2019-posters-abstracts

Page 46

Notes:

allied

academies

Journal of Clinical and Experimental Toxicology | Volume: 3

February 21-22, 2019 | Paris, France

International Conference on

Environmental Toxicology and Pharmacology

Antidepressant-like effects of HSR extract in a Restraint-Induced Chronic Stress model

Mi Young Lee

Korea Institute of Oriental Medicine, South Korea

orticosterone signaling is involved in stress and

depression, as well as in depression pathophysiology.

Using an animal model of restraint stress, we investigated

the effects of HSR on depressive-like behaviors and on

the expression levels of serotonin, corticosterone, and

neurotrophic factors in the brain. The mice were exposed

to restraint stress for 2 h per day over a period of 3 weeks

and orally treated with HSR (100, 200, or 400 mg/kg/day).

Administration of HSR not only reduced the immobility

times of the restraint-stressed mice in the forced swimming

and tail suspension tests but also significantly increased

sucrose preference in the sucrose preference test. HSR

also significantly reduced the levels of corticosterone

and increased the levels of serotonin in the plasma. The

extract also increased the phosphorylation level of cyclic

AMP response element-binding (CREB) protein and the

expression level of brain-derived neurotrophic factor (BDNF).

J Clin Exp Tox, Volume 3

DOI: 10.4066/2630-4570-C1-006