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Journal of Clinical and Experimental Toxicology | Volume: 3

February 21-22, 2019 | Paris, France

International Conference on

Environmental Toxicology and Pharmacology

Notes:

J Clin Exp Tox, Volume 3

DOI: 10.4066/2630-4570-C1-006

Effects of zinc chloride on Zebrafish locomotion, circadian rhythm, social behavior and memory:

Correlation between Toxicity and Neurobehavior changes

Sreeja Sarasamma

Chung Yuan Christian University, Taiwan

inc is a micronutrient at low level but at high concentrations

leads to environmental contamination and causes health

problems. The aim of this study was to evaluate the effects of

Zinc Chloride (ZnCl

) exposure on cognition and locomotion

behavior in adult zebrafish (Danio rerio) and correlate these

findings with different tissue accumulation of Zn, overall brain

AChE and ROS level, Cortisol and Metallothionine levels in the

nervous system. Although low level heavymetal exposure poses

a potential risk to the zebrafish larvae, little or no data about the

effects of ZnCl

exposureon zebrafish adult

therefore,

exposed adult zebrafishes for 4 days (0.5,1 and 1.5mg/L)

displayed decreases locomotor behavior, such as average speed

and time in upper zone and an increase speed of meandering.

Interestingly, adult fishes exposed to ZnCl

for 4 days showed

impaired frigid long-termmemory in the passive avoidance test.

Furthermore, zinc chloride treated fish showedmemory deficit,

increased ROS and AChE levels and decreased locomotor and

swimming activities compared to control. A significantly positive

correlation was observed between memory and AChE activity,

as well as between locomotion and ROS production. These

results indicate that acute exposure to ZnCl

in adults leads to

anxiogenic effects, impaired memory and decrease aggressive

behavior that might be associated with damage caused by

this metal in the CNS, particularly in the cholinergic system.