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Res Rep Gynaecol Obstet 2017 | Volume 1 Issue 4
November 02-03, 2017 | Chicago, USA
Embryology and In vitro Fertilization
World Congress on
The immunopathology of regression in keratoacanthoma
Fathia A Bayoumi
Medcare Hospital, UAE
Background:
Keratoacanthoma (KA) has a tendency for
either progression or spontaneous regression. Regression
is a phenomenon present in a variety of cutaneous lesions.
It is likely that certain immunologic mechanisms explain the
phenomenon of spontaneous regression occurring in KA.
Causes and detailed mechanism of this regression are still
not completely elucidated. Recent studies suggested that
the tumor regression is dependent mainly on the stromal
immune response.
Aim:
As a first step in confirming or refuting this hypothesis,
we did an immunohistochemical study of KA. Also we
correlated between the tumor size, rate of proliferation and
stromal infiltration by cytotoxic T lymphocytes which release
granzyme-B.
Methods & Results:
This is a case series study done on 20
cases of KA that were examined and clinicopathological
findings were reviewed. Immunohistochemical stains using
PCNA, P53 and granzyme-B were done. PCNA showed
positive staining in all cases (100%) with significant positive
correlation with the tumor size (0.5, p<0.02). P53 was
positive in 16 cases (80%) with highly significant positive
correlation with the tumor size (0.63, p<0.0028). Granzyme-B
was positive in the stromal lymphocytes and histiocytes only
in 6 cases (30%) with highly significant negative correlation
with the tumor size (-0.79, p<0.0001). Negative correlation
between PCNA overall score and granzyme-B was evident
(-0.37) and between P53 overall score and granzyme-B also
(-0.38). The mean total score for granzyme-B was higher
(1.04+0.23) in tumors less than 1 cm in size if compared with
that in tumors more that 1cm in size (0.66+0.12).
Conclusion:
The increased release and/or activity of
granzyme-B as CTL-mediated response were considered to
be a central effector mechanism in tumor regression in KA.
Speaker Biography
Fathia A Bayoumi is graduated from the faculty of medicine, Ain-Shams university
(MBBCH), Masters and PhD in Pathology from Zagazig University, Egypt is working
in Medcare hospital United Arab Emirates as a consultant histopathologist. She
worked as the Chief Academic Officer and Head of Department of Pathology, Dubai
Medical College, United Arab Emirates.. In addition, she obtained a Masters in Health
Professions Education from Maastricht and Suez Canal University. With her vast
experience as Professor and Head of Pathology department, in addition to her role
as Chief academic officer, Prof. Fatehia is acclaimed to be one of the best teachers by
the students. Having more than twenty four years of experience in medical education
in the UAE, she has pioneered many significant improvements in medical education in
DMC. During the two years, when she served as Dean of College, she geared the college
through several key milestones such as integration of curriculum and international
accreditation, way back in 1998, taking DMC to the forefront of integrated teaching
in the country. She continues to give leadership to the academic affairs, continuously
updating the curriculum and introducing innovative tools of education. Her urge to
excel has taken the educational system of the college to the next level through sharing
of best practices and strategic partnerships. Prof. Fathia brings to the college, the latest
in international health sector through her participation in international societies like
International Academy of Pathologists. Prof. Fatehia enjoys a respectable position as
one of the top academic pathologists in the country. Her involvement in the Emirates
Pathologists’ Association has led to DMC hosting their meeting on several occasions.
She is She is a member of international academy of pathologists -Arab Division (IAP-
AD), in United States and Canadian Society of Pathologists (USCAP) and Emirates
Medical association (EMA). Prof. Fathia is an avid researcher and serves as a research
guide and reviewer to several groups of students and doctors. Her areas of research
include immunohistochemistry and genetic profiles of different disorders, in which she
has published several research articles. She has participation as attendance, speaker,
presenter in 38 scientific conferences and workshops and published 37 scientific
papers in reputable journals. Prof. Fathia Ali Bayoumi, is the Secretary General of
the Medical Research Fund (MRF), DMC which aims to improve the standards of
healthcare nationally and regionally through research programs. The Medical Research
Fund is highly dependent on a national effort that engages individuals, groups and the
corporate sector to usher in a new era of medical achievement in the United Arab
Emirates. The Medical Research Fund was launched in April 2008 and received a lot of
medical research proposals out of which 12 have been accepted for the fund.
e:
drfatehia@hotmail.com