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Res Rep Gynaecol Obstet 2017 | Volume 1 Issue 4
November 02-03, 2017 | Chicago, USA
Embryology and In vitro Fertilization
World Congress on
Proper autophagy is indispensable for early embryonic morphogenesis
Xuesong Yang, Guang Wang
and
Xin Cheng
Jinan University, China
P
eople have known that autophagy plays a very important
role in many physiological and pathological events. But
autophagy role on embryonic morphogenesis still remains
obscure. Using embryonic chick and mouse models, we first
demonstrated that autophagy relevant genes such as
Atg7
,
Atg8
and
Beclin1
express in many germ layers at gastrula
embryos, implying that autophagy might be involved in
those embryonic morphogenesis. Further interference
of autophagy with autophagy inhibitor or activator could
lead the malformations of heart tube, abnormal cell
migration and differentiation of neural crest cells, improper
angiogenesis etc. Down-regulation or up-regulation of
Atg7
gene also caused the similar phenotypes
in vivo
and
in vitro
. The corresponding mechanisms for each dysplasia
were investigated in further detail. Taken together, our
experimental data revealed that autophagy is indeed involved
in regulating the crucial gene regulation and corresponding
morphogenesis at early embryo development.
Speaker Biography
Xuesong Yang is currently working as a Professor at Jinan University Medical College,
China. He received his Bachelor’s and Master’s degree from Harbin Medical University,
China and then received his Doctorate from Tokyo Medical and Dental University
School of Medicine, Japan. After having worked in University of Manchester and
University of Dundee, UK for 11 years, he took the position at Jinan University Medical
College. His research interests contain: exploring embryos as the possible models
for stem cell applications on regenerative medicine, the regulations of coordinated
signaling pathways on mesoderm and neural crest cell migration during gastrula
embryo development, the investigation of gene-regulatory elements on birth defects.
So far, he has published 86 SCI scientific papers including Developmental Cell, PNAS,
Current Biology and Development, Developmental Biology and Oncogene.
e:
yang_xuesong@126.com