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Res Rep Gynaecol Obstet 2017 | Volume 1 Issue 4
November 02-03, 2017 | Chicago, USA
Embryology and In vitro Fertilization
World Congress on
New monoterpenoid by biotransformation of thymoquinone using Aspergillus niger
Mohammad Yasin
1
Middle East University, Lebanon
2
University of Karachi, Pakistan
M
icroorganisms have been used extensively for
hydroxylation of terpenoids since their enzymes
catalyze reactions with high regio- and stereospecifity. Their
ability to oxidize terpenoidal compounds has an immense
synthetic and commercial importance. The hydroxylation of
a large number of substances, including terpenoids, has been
studied by employing a variety of microorganisms. However,
no studies on the transformation of thymoquinone, by
fungi have been reported in the literature. Thymoquinone
(2-Isopropyl-5-methyl-[1,4]benzoquinone,
C10H12O2)
(1), a monoterpenoid isolated from the seeds of Nigella
sativa, has been shown to have anti-tumor activity
against liver, prostate, colon, breast, lung and pancreatic
cancer. Thymoquinone (1) has been also shown to have
antioxidant, analgesic and anticonvulsant effects. Microbial
transformation of thymoquinone (1) by suspended cell-
cultures of the plant pathogenic fungus Aspergillus niger
resulted in the production of three metabolites. These
metabolites were identified as 5-isopropyl-2-methyl-2,4-
cyclohexenone lactone (2), hydroxythymoquinone (3), and
4-hydroxy-2-isopropyl-5-methylphenol (4) by different
spectroscopic methods. Metabolite 2 was found to be a new
compound. Compound 4 showed potent antioxidant activity.
Speaker Biography
Mohammad Yasin Mohammad has obtained his BSc degree (Chemistry) in 2004 from
the University of Jordan in Amman, Jordan, MSc degree (Organic Chemistry) in 2008
from the University of Karachi, Karachi, Pakistan, and PhD degree (Organic Chemistry)
recently in 2013 from HEJ Research Institute of Chemistry, International Center for
Chemical and Biological Sciences, Karachi-75270, Pakistan. He is currently working as
Assistant Professor at the Faculty of Pharmacy, Middle East University, Amman-11831,
Jordan. His research interests are in natural products chemistry and in microbial
biotransformation of steroids as well. His future plan is to establish a research in the
field of Natural Products Chemistry. He wishes to contribute in raising standards of
education and research in Jordan.
e:
mhm17feb@hotmail.com