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J Pharmacol Ther Res 2017 Volume 1 Issue 2
November 02-03, 2017 Chicago, USA
4
th
International Congress on
International Conference and Exhibition on
Drug Discovery, Designing and Development
Biochemistry, Molecular Biology: R&D
&
Investigation of the biochemical mechanism of action of antioxidants in the prevention of cancer
Kissi Mudie
Ethiopian Public Health Institute, Ethiopia
Background:
The safe use of medicines is a critical issue for all
health care professionals. Cancer refers to a group of diseases
that are associated with a disturbance in the control of cell
growth and metabolism. Indeed, the unbalanced control of
cellular proliferation is a primary characteristic of cancer cells
and, as such, any molecule capable of inhibiting cancer cell
proliferationmay alsobeuseful as apotential chemo-preventive
agent. Throughout history, antioxidants have been the most
significant source of anticancer and chemopreventing agents.
More than 1,000 different phytochemicals are already proved
to possess interesting chemopreventing activities. Antioxidants
consist of a wide variety of biologically active phytochemicals
including phenolics, flavonoids, carotenoids, etc. that have been
shown to suppress early and late stages of carcinogenesis.
Objective:
The objective of this study was to review recent
biochemical and molecular mechanisms, in relation to natural
and synthetic chemopreventing substances (antioxidants) for
cancer control and management.
Findings:
Antioxidants exert anticancer effects via a variety
of mechanisms, including removal of carcinogenic agents,
modulation of cancer cell signaling and cell cycle progression,
promotion of apoptosis andmodulation of enzymatic activities.
Conclusion:
Thisreviewprovidesanupdatedandcomprehensive
overview on the anticancer effects of antioxidants
in-vitro
and
in-vivo
animal models including recent intervention studies.
Finally, possible mechanisms of action involving antioxidant
and pro-oxidant activity as well as interference with cellular
functions are discussed.
Speaker Biography
Kissi Mudie has completed his MSc in Medical Biochemistry from Addis Ababa
University, School of Medicine. He is the Director of National clinical chemistry
laboratory, Ethiopian Public Health Institute. He has published more than 16 papers in
reputed journals and has been serving as Researcher.
e:
kissimudiey@yahoo.com