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J Pharmacol Ther Res 2017 Volume 1 Issue 2
November 02-03, 2017 Chicago, USA
4
th
International Congress on
International Conference and Exhibition on
Drug Discovery, Designing and Development
Biochemistry, Molecular Biology: R&D
&
The new role of lipin1 in myogenic progenitor differentiation to muscle and adipose tissues
Hongmei Ren
Wright State University, USA
B
rown adipose tissue and skeletal muscle originate from
common myogenic factor 5-expressing (Myf5) progenitors.
Despite, the great promise of directing Myf5+ progenitor cells
in the treatment of obesity, little is known about what controls
the progenitors commit to the brown adipogenic lineage. Lipin1
catalyzes the penultimate step in triglyceride synthesis and
play an important role in promoting adipogenic differentiation
in Myf5neg fibroblast cells. Surprisingly, depletion of lipin1 in
Myf5+ progenitors in our newly generated Lipin1Myf5cKO
mice promotes brown adipose tissue conversion indicated by
inhibition of skeletal muscle development and expanded brown
adipose tissue formation in the dorsal cervical region compared
to control littermates. In this seminar, I will discuss about the
mechanism of lipin1 in regulating skeletal muscle development
and commitment and differentiation of skeletal muscle and
brown adipose tissue, and affects the cell fate switch between
myogenesis and adipogenesis.
Speaker Biography
Hongmei Ren is currently an Assistant Professor in the Department of Biochemistry
and Molecular Biology at the Wright State University. She has received her
Postdoctoral training in Cardiovascular Research Center at University of Kentucky. Her
research interests focus on lipid metabolism, and their effects on cardiac and skeletal
muscle function. Her laboratory recently revealed a previously unknown role of lipin1
(phosphatidic acid phosphatase) in controlling myogenic cell fate commitment.
e:
Hongmei.ren@wright.edu