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J Pharmacol Ther Res 2017 Volume 1 Issue 2

November 02-03, 2017 Chicago, USA

International Congress on

International Conference and Exhibition on

Drug Discovery, Designing and Development

Biochemistry, Molecular Biology: R&D

Hydralazine induces stress resistance and extends lifespan in

C. elegans

via Nrf2/SKN-1 pathway

Hamid Mirzaei

University of Texas Southwestern Medical Center, USA

xidative stress increases gradually with aging and steadily

diminishes the cell’s ability to maintain homeostasis.

Nuclear factor (erythroid-derived 2)-like 2 and its

C. elegans

ortholog, SKN-1, are transcription factors that play a pivotal

role in the oxidative stress response, cellular homeostasis and

lifespan. But like other defense systems, the Nrf2-mediated

stress response is compromised inaging andneurodegenerative

diseases. In this study, we provide evidence that hydralazine, a

drug used for treatment of hypertension, is a bona fide activator

of the Nrf2/SKN-1 pathway. We demonstrate that hydralazine

protects Alzheimer’s disease model cells and

C. elegans

from

chemical stressors linked to neurodegenerative diseases. We

also show that hydralazine extends lifespan and health in

C. elegans

. Hydralazine is an FDA approved drug; therefore,

we suggest it is an excellent candidate for clinical trials for

treatment of age-related disorders. Hydralazine may also offer

general health benefits for the aging population.

Speaker Biography

Hamid Mirzaei’s research is focused on finding the target of novel and FDA

approved compounds using a combination of Proteomics, Computational Biology

and Biochemistry. Many FDA approved drugs are currently in use without clear

understanding of their mechanism of action. On the other hand there are quite a few

well-characterized natural products with unknown targets. His research is focused on

understanding the drug’s mechanism of action by identifying the target of the drugs

and their cellular and organismal phenotypes.