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Page 73
allied
academies
J Pharmacol Ther Res 2017 Volume 1 Issue 2
November 02-03, 2017 Chicago, USA
4
th
International Congress on
International Conference and Exhibition on
Drug Discovery, Designing and Development
Biochemistry, Molecular Biology: R&D
&
H
unteria umbellata
seeds are used ethnomedicinally to
treat obesity, pain, swellings, anaemia and as immune
booster. However there has been no scientific proof of its
uses in the managements of hypertension ethnomedicinally,
hence the aim of this study, therefore, was to investigate
the preliminary phytochemical properties of aqueous and
ethanolic crude extracts of
Hunteria umbellata
seeds and
its physiological effects on salt induced hypertension in
experimental animals. The phytochemical studies were
carried out according to the methods of Association of
Official Analytical Chemist (A.O.A.C). Twenty-five (25) female
adult Wistar rats were administered with 8% of NaCl (salt)
for 2 weeks and shared into five groups of five animals in
each group. Group I was normal control, Group II was
treated with 8% of NaCl, while Group III was treated with 8%
of NaCl and 40 mg propranolol. Group IV was treated with
8% of NaCl and aqueous extract (500 mg/kg) of
Hunteria
umbellate
and Group V was treated with 8% of NaCl and
ethanolic extract (500 mg/kg) of
Hunteria umbellata
. The
results of the quantitative phytochemical components of
aqueous and ethanolic extracts revealed the presence of
oxalate, phytate, tannins, flavonoids, saponins, alkaloids,
phenols, cyanogenic glycoside and anthraquinones. The
blood pressures of the animals were taken before and after
salt treatments at a weekly interval. The administration of
the standard drug (propranolol) caused a reduction in high
systolic blood pressure of the hypertensive experimental
animals from 162.00 mmHg to 134.00 mmHg, while the
diastolic pressure was recorded to fall from 103.00 mmHg
to 73.67 mmHg. The administration of aqueous extract
of
H. umbellata
seeds caused a reduction of the systolic
blood pressure of the hypertensive experimental animals
from 159.20 mmHg to 136.25 mmHg, while the diastolic
blood pressure was recorded to fall from 103.80 mmHg to
80.25 mmHg. The administration of ethanolic extract of
H.
umbellata
seeds caused a reduction in systolic blood of the
hypertensive experimental animals from 160.20 mmHg to
133.00 mmHg, while the diastolic pressure was recorded to
drop from 102.20 mmHg to 76.75 mmHg. The results of this
study showed that the systolic and diastolic blood pressure
of the animals treated with the ethanolic extract and
propranolol were reduced compared to control (p<0.05). The
histological results of both aqueous and ethanolic extracts
of
H. umbellata
seeds revealed appreciable recovery of the
degenerating tissues. Medicinal plants have become a great
source of medicine for the treatments and managements of
hypertension and researches on the medicinal values of
H.
umbellata
seeds and its therapeutic effects to health sector
should be encouraged.
e:
frederick.ekhaise@uniben.eduPreliminary investigation of the phytochemical properties of aqueous and ethanolic crude extracts of
Hunteria umbellata K.
(Schum) seeds and its antihypertensive effects on salt induced hypertension in
Wistar Rats
O C Udinyiwe, F I Okolafor, S Uwansojie
and
F O Ekhaise
University of Benin, Nigeria