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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Chemistry World 2017
Page 69
November 13-15, 2017 Athens, Greece
7
th
World Congress on
Chemistry
Smart polymers for drug release and cellular
control - triggered release and activation
Mark Bradley
University of Edinburgh, United Kingdom
My talk will be in three parts. Firstly, I will describe polymer
microarray technology, which has been developed by the
Bradley group. I will introduce the technology, including our
unique inkjet mediated fabrication methodologies (which
allow over 7000 different substrates to be fabricated on a single
glass slide) and describe how this approach has been used in
a large number of stem cell based applications. Secondly, I
will discuss how Palladium and Copper catalysts entrapped
within a polymeric scaffold can mediate chemistry inside
cells, including the formation of both new C-C bonds but also
the liberation of “caged” compounds (e.g. drugs). Finally, I
will describe some of the group’s polymer chemistry in which
Diels-Alder chemistry is used to trigger cargo liberation from
nanoparticles within a biological context.
mark.bradley@ed.ac.ukJ Biotech and Phyto 2017