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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Chemistry World 2017
Page 67
November 13-15, 2017 Athens, Greece
7
th
World Congress on
Chemistry
Intracellular delivery of biomacromolecules
Nathalie Lavignac
University of Kent and Greenwich at Medway, United Kingdom
Efficient delivery of non-permeant therapeutic agents with
intracellular therapeutic targets is challenging. Over the
years, methods using viral and/or non-viral vectors have
been developed. Synthetic polymers, often considered a safer
alternative, may be tailored to improve cytoplasmic access and
modulate cell specific targeting. Poly(amidoamine)s (PAAs)
are a family of synthetic functional polymers developed for
use as polymer therapeutics.They are synthesized by Michael
addition polymerization, are generally water soluble and
display pH-dependent membrane activity. We will discuss the
biological rational for the development of these polymers and
review their application for the delivery of macromolecular
drugs (e.g. proteins, oligonucleotides).
n.lavignac@kent.ac.ukJ Biotech and Phyto 2017