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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9
th
World Congress on
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9
ISSN: 2249-622X
A comprehensive study on the bioactive compounds of pharmaceutical interest
present in
Cannabis sativa L
.
Federica Pellati
University of Modena and Reggio Emilia, Italy
C
annabis sativa I
. is a dioecious plant belonging to the
Cannabaceae
family. The main compounds present in
this plant are represented by cannabinoids, flavonoids and
terpenes. Among cannabinoids, Δ
9
-tetrahydrocannabinol
(Δ
9
-THC) is responsible for Cannabis psychoactive effects.
Other main cannabinoids include tetrahydrocannabinolic
acid (THCA), cannabinol (CBN), cannabidiol (CBD) and
cannabidiolicacid(CBDA).Forwhatconcernsotherphenolic
compounds, flavonoids have also been identified in C.
sativa
,belongingmainlytoflavonesanddihydrostilbenoids.
In particular, cannflavin A and B represent
Cannabis
-
specific methylated isoprenoid flavones. Terpenes
represent the largest group of
Cannabis
components
and they are responsible for its aromatic properties.
In this view, a detailed study on the above-mentioned
compounds is highly recommended to guarantee a
rational use of
Cannabis
for therapeutic purposes. In the
light of all the above, the present work was aimed at the
comprehensive analysis of the bioactive components
present in C.
sativa
by means of innovative methods. In
particular, the profiling of cannabinoids in extracts was
carried out by means of a HPLC-UV/DAD, ESI-MS and MS
2
method, together with a selective extraction protocol, by
taking advantage of the innovative fused-core technology
of the stationary phase. A new RP-HPLC-UV/DAD, ESI-MS
and MS
2
method, together with an optimized extraction
procedure, was developed as well and applied for the
determination of phenolics (including
cannflavin A,
cannflavin B
and
canniprene
). The study on
Cannabis
volatile compounds was performed by developing a new
methodbasedonHS-SPMEcoupledwithGC-MSandGC-FID.
The methods described above were applied to both drug-
type and fibre-type
Cannabis
samples. These procedures
were found to be suitable for the multi-component
chemical analysis C.
sativa
inflorescences in order to
ensure their quality, efficacy and safety.
Speaker Biography
Federica Pellati graduated cum laude in 2000 in Pharmaceutical
Chemistry and Technology at the Faculty of Pharmacy of the University
of Modena and Reggio Emilia. In 2004 she got a PhD degree in
Pharmaceutical Sciences. Then she had a post-doctoral fellowship
position in Medicinal Chemistry and in 2006 she got a position
of Assistant Professor in Medicinal Chemistry at the University of
Modena and Reggio Emilia. In 2014, she got the Italian Professorship
Qualification (ASN 2012) as an Associate Professor in Medicinal
Chemistry.
Her research activity is focused on the development of innovative
techniques for the extraction and analysis of bioactive natural products,
and on the isolation of new bioactive compounds of natural origin. She
has a number of national and international research collaborations and
she participates to peer-reviewed research projects.
She is the author of more than 60 papers in ISI indexed international
journals, n. 3 book chapters, n. 4 proceedings in international journals,
n. 2 patents and more than 90 congress communications (oral and
poster). She is an associated editor, an editorial board member and a
reviewer for international Journals in the area of Pharmaceutical, Plant
and Food Analysis.
e:
Federica.pellati@unimore.itFederica Pellati, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-020
Notes: