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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9
th
World Congress on
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9
ISSN: 2249-622X
Engineered Metal Oxide Nanoparticles, Nano-Bio Interaction and Toxicology
Muhammad Furqan Danish
Antalya Bilim University, Turkey
M
etal oxide nanoparticles (NPs) are usually utilized
nanomaterials. The Nano-level size offer these metal
oxides capability of novel properties resulting in top of
the line advancements as well as in customer arranged
applications. Nanotechnology is most recent undertaking,
which has progressed hugely in most recent couple of
years, however regardless it needs well laid rules and
top to bottom toxicological investigations. How these
metal oxide NPs and their ionic structure will respond in
fluctuating organic interface and long-haul impacts are
not very much characterized? In our exploration we have
made an endeavor to think about the intense and ceaseless
impacts of the normally utilized metal oxide nanoparticles,
Al2O3 NPs and ZnO NPs in Drosophila melanogaster.
The presentation portion incorporates 0.1-1mM NPs in
Drosophila diet and flies were uncovered all through their
life expectancy. Toxicological impacts post presentation was
assessed on different parameters like: climbing capacity,
fruitfulness, life expectancy, oxidative pressure, apoptosis
and rate of deviant phenotype in ensuing ages. Critical
decrease in climbing capacity was seen in parent flies on
seven days introduction to these NPs. Critical increment
in receptive oxidative species and apoptotic cells was
seen in hatchlings hemocytes through DCF-DA and TUNEL
test. Particular abnormal phenotypic changes like twisted
portioned thorax, loss of wing, distorted body symmetry
was seen in resulting age on ZnO NPs presentation.
Perpetual introduction of Al2O3 NPs brought about flies
with pigmented and sectioned thorax and disfigured
legs. Our perceptions obviously delineated that these
nanoparticles can make negative impacts consequent ages.
Speaker Biography
Muhammad Furqan Danish done BS organic chemistry from Pakistan.
He completed his thesis work on the topic of synthesis of nanoparticles
from sea weeds. He has 2 years pharmaceutical experience as a quality
control analyst and handling multi instruments in pharmaceutical
industry. And then he came turkey for higher education and got an
admission Antalya Bilim University and doing MBA.
e:
danish.furqan@yahoo.comMuhammad Furqan Danish, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-020