chemistry-2019-keynote

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allied
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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9th World Congress on
Page 56
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9 ISSN: 2249-622X
Obesity is a global public menace now-a-days, with
approximately 315 million people are suffering from
this serious health problem. Indigenous herbal medicines
may play a very important role in managing obesity as
the most of the ailments can be cured through herbal
therapy. The complex mixtures of phytochemicals in
ethno-medicines often contain that have additive or
synergistic interactions. Fruits of Garcinia and unique
source of Hydroxycitric acid have a distinct sour taste and
has been used for centuries in South-East Asia region to
make meals more filling. Inhibition of carbohydrate to fatty
acid conversion reaction can lead to obesity control and
can be accomplished by assay of Hydroxycitric acid that
stops the ATP-citrate lyase formation which is responsible
for lipogenesis. (-)-HCA is a derivative of citric acid and
found in Garcinia fruits as the principal acid. Our study
deals with the subjugating effects of (-)-HCA on lipogenesis
in animal model. Wistar rats were fed with a high-fat diet
(HFD, 45 kcal% fat) for 60 days. They were given access
to food and distilled water ad libitum. The body weights
were measured weekly and several important parameters
viz. as Cholesterol, Triglycerides, HDL-D, Cholesterol were
recorded. Statistical analyses were performed using
SPSS13.Significant changes in body weight between
the groups were observed. Supplementation of (-)-HCA
significantly lowered visceral fat accumulation in Wistar
rats. Our findings establish that Hydroxycitric acid is
responsible for repression of lipogenesis in Wistar rats and
could be suggested an antiobesity agent.
Speaker Biography
Bijoy Neog has his expertise in Cytogenetics & Plant Breeding. He
has worked in biochemical mechanism self-incompatible of Camellia
sinensis for his doctoral thesis. He has keen interest in multidisciplinary
approaches in biological sciences and has authored of over 50 research
papers and book chapters in various National and International
Journals. His special interest is in the field of lesser known fruit species
of pharmaceutical importance from eastern Himalayan Region of
Indo-China Border. He was awarded prestigious Chinese Government
Scholarship for Post-Doctoral Research in 2005-06. He has P.G.teaching
experience for 24 years and presently working as Professor in the
Department of Life Sciences, Dibrugarh University, Assam, India.
e:
Bijoy Neog
Ankur Gogoi and Nabajyoti Gogoi
Dibrugarh University, India
Role of Garcinia fruits in Obesity control
Bijoy Neog et al, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: