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May 13-14, 2019 | Prague, Czech Republic
Chemistry and Medicinal Chemistry
9
th
World Congress on
Page 51
Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 9
ISSN: 2249-622X
Miguel Holgado
Universidad Politécnica de Madrid, Spain
Arrays of Resonant Nano Pillars (RNPs) for advanced optical
biochemical sensing and first steps in tissue-on-a-chip
I
n recent works we demonstrated the suitability of using
resonant nanopillars (R-NPs) arrays for biochemical sensing
and label-free biosensing. The performance comparison
with other photonic structures suggest the suitability of this
transducers and bio-transducers for many other applications.
Moreover, the vertical interrogation of the biochips,
simplifies the readout platforms and allows a high degree
of multiplexing. The multiplexing results showed a highly
reproducibility suggesting the potentially of using R-NPs for
multiplexed chemical sensors and biosensors. On the other
hand, most of the biosensing systems are based on chemical
development or amplification (labeled technologies). This is
the case of ELISA tests or lateral flow devices. The challenge
for label-free PoC devices is to achieve a competitive LoD
avoiding this chemical amplification and working with
simple drops of samples in an easy-to-use manner. Thus,
being the LoD the main figure of merit to compare PoCs, it
is worthy to mention that this figure can be improved mainly
by enhancing the transducer sensitivity or by reducing the
uncertainty of the PoC readout systems. On one hand, the
optical transducers employed is decisive for having high
sensitivity, and on the other hand, the optical reader (PoCs)
is fundamental for readout the signal with low uncertainty
and stability. In, fact the LoD can be estimated by the ratio
between the uncertainty and the sensitivity and it can be
considered the main figure of merit to compare different
biosensing systems. The application of these technologies
(transducers and readers) may play an important role in the
development of tissue-on-a-chip approaches. We present in
this paper the first steps carried out in our research group in
tissue-on-a-chip models.
Speaker Biography
Miguel Holgado received his bachelor’s and master’s degree in Electrical
Engineering from Technical University of Madrid (UPM) (1996), and
Doctoral degree (Ph.D.) at the Institute of Material Science (ICMM)
belonging to the Spanish National Research Council CSIC (2000). He is
Deputy Vice-Rector for Innovation, group leader of the Optics, Photonics
and Biophotonics at the Center for Biomedical Technology CTB-UPM, and
professor at the Applied Physics and Material Engineering Department of
Industrial Engineering School (ETSII-UPM). He worked as: R&D engineer
at Laser Section at the Spanish Ministry of Defense and responsible
for RAMAN spectroscopy service Lab at ICMM-CSIC. He was process
engineer at Lucent Technologies Microelectronics for 4 years, Spanish
representative in the 5th and 6th European R&D Framework Programme
at the Center for Industrial Technology (CDTI), Sub-director of RTD
projects at Nanophotonics Technology Center at Technical University of
Valencia and Head of European Communities Unit at CSIC. He has led and
participated in 34 research projects: 9 European, 19 National and regional
as well as another industrial and R&D initiatives. He is author/co- author
of more than 150 scientific publications, which have been cited more than
2200 times and the inventor of 6 patents applications. In addition, he is
also founder of Bio Optical Detection; a spin-off company (BIOD S.L.) which
develops optical Point-of Care devices and offers IVD screening services.
e:
m.holgado@upm.esMiguel Holgado, Asian J Biomed Pharmaceut Sci, Volume:9
DOI: 10.4066/2249-622X-C2-019
Notes: