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Journal of Nutrition and Human Health | Volume 2
&
October 29-30, 2018 | London, UK
Joint Event
Nutrition and Fitness
16th International Conference on 3rd World Congress on
Card i o l ogy
Biological and immunological aspects of iron deficiency anemia in cancer development: A narrative
review
Fatema Tuz Zohora, Katayoon Bidad, Mostafa Moin and Zahra Pourpak
Tehran University of Medical Sciences, Iran
I ronDeficiencyAnemia(IDA)isamajorandglobalpublichealth
problem in general populationmainly affecting school-aged
children and women with serious consequences on physical
andmental health. It may be a risk factor for the development
of cancer. IDA changes the microenvironment of the human
body by affecting both biological and immunological systems.
IDA is one of the leading causes of the imbalance between the
pro-oxidant and antioxidant system (REDOX) in the body and
generates excessive Reactive Oxygen Species (ROS) which are
the crucial factors for oxidative damage of cellular structures
like mitochondria, DNA leading to DNA damage and genomic
instability, those are the hallmarks of cancer development.
Moreover, IDAcan severely affect thebiogenesis/expressionof
microRNAs. IDA also interrupts the oxidative phosphorylation
energymetabolismand intestinal Cytochrome-P450 systems.
Additionally, IDAmaydiminish the cytoprotective roleof Heme
Oxygenase-1 (HO-1) against oxidative stress from external
environment. During IDA, thebody greatly suffers fromhypoxia
which may activates multi-cellular signaling pathways for cell
survival, tumor progression, angiogenesis and metastasis.
Besides, immune system is also affected by hypoxia. IDA cause
immunological dysfunctions against invading pathogens. It
decreases the proliferation and cytotoxic aswell as phagocytic
activities of the immune cells against tumor cells throughdown
regulation of different immunological pathways which might
predispose iron deficient individuals to cancer development.
Speaker Biography
Fatema Tuz Zohora is a PhD student in Immunology, Asthma and Allergy Research
Institute (IAARI), Tehran University of Medical Sciences (TUMS), Tehran, Iran. She holds
her D.V.M and . from Bangladesh Agricultural University. She is currently working
with Next Generation Technique (NGS) in the field of Immunodeficiency at IAARI.
She received Bangladesh Government Junior Scholarship and TUMS international
Scholarship. Her research interest also includes molecular genetics and gene editing
technologies.
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