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CANCER STEM CELLS AND

ONCOLOGY RESEARCH

International Conference on

Journal of Medical Oncology and Therapeutics

Volume 3

Aurélie Tchoghandjian, J Med Oncl Ther 2018, Volume 3

INHIBITOR OF APOPTOSIS PROTEINS

DETERMINE GLIOBLASTOMAS STEM-

LIKE CELLS FATE IN AN OXYGEN-

DEPENDENT MANNER

Aurélie Tchoghandjian

Axe Marseille Université, France

mac mimetics (SMs) are inhibitor of apoptosis proteins (IAPs)

antagonists. In glioblastomas (GBs), SMs can trigger apoptotic and

non-apoptotic processes1, 2, 3. As GBs are highly hypoxic, we investigated

SM GDC-0152 effect in GB stem-like cells according to oxygen level. We

showed that in an environment rich in oxygen (normoxia), GDC-0152

induced loss of stem-cell properties. Unexpectedly, in an environment

deprived of oxygen (hypoxia), it triggered apoptosis and decreased cell

proliferation. Analysis of Serine-Threonine Kinases activation upon GDC-

0152 treatment revealed involvement of different signaling pathways

according to oxygen level. In normoxia, NF-κB pathway was activated and

in hypoxia, GDC-0152 efficacy was ATR- and TNFα-dependent. This work

shows that GDC-0152 triggers anti-tumoral effects whatever the tumoral

oxygen pressure, therefore SMs appear as promising molecules in GBs

treatment.

Aurélie Tchoghandjian is currently working in

INP – Institut de Neurophysiopathologie, Axe

Marseille Université, France

BIOGRAPHY