cancer-2018-posters-abstracts

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Journal of Medical Oncology and Therapeutics | Volume: 3

July 23-25, 2018 | Moscow, Russia

World Cancer Congress

Synthesis of metallacarboranes-based delocalized lipophilic cations for diagnostics and Cancer

treatment

Dugin Sergey, P Belov, E Gurkova, V Pasko

and

P Storozhenko

JSC RSC GNIIChTEOS, Russian Federation

etallacarboranes represent the wide class of

polyhedral boron compounds with low toxicity, high

boron content and catabolic stability. Applied in boron

neutron capture therapy metalcarboranes derivatives are

of interest. All of that sets apart metallacarboranes in the

separate broad group of perspective pharmacophores.

Carboranes containing the Delocalized Lipophilic

Cations (DLCs) arouse big interest. DLCs are perspective

compounds for diagnostics and cancer treatment. Eight

compounds based on fluorescent dyes Rodamine 6G, B,

were synthetized and characterized in our laboratory.

Developing this direction, the optimal methods of bis

(dicarbollide) cobalt-based DLCs syntheses were invented.

Speaker Biography

Dugin Sergey has completed his PhD at the age of 25 years from RSC GNIIChTEOS,

Russian Federation. He is the leading scientist in GNIIChTEOS. He has over 200

publications that have been cited over 200 times, and his publication H-index

is 20 and has been serving as an editorial board member of reputed Journals.