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Journal of Medical Oncology and Therapeutics | Volume: 3
July 23-25, 2018 | Moscow, Russia
12
th
World Cancer Congress
Genomic analysis of racial differences in triple negative Breast Cancer
Lesleyann Hawthorn
Georgia Cancer Center, USA
T
riple negative breast cancer (TNBC) is more prevalent in
AfricanAmericans(AAs),hasamoreaggressiveclinicalcourse
including a higher mortality rate and increased occurences
of metastases. This study was designed to determine if racial
differences at the molecular level might explain the more
aggressivephenotype inAAs.Mutationprofiling,wasperformed
on 51 AA and 77 CA tumor/ normal pairs. Transcript expression
analysis was performed on 35AA and 37CA. Genes with high
frequencymutationratessuchasMUC4andTP53werecommon
to both racial populations, however genes that were less
frequently mutated differed between the races suggesting that
those cause the more aggressive nature of TNBC in AA women.
Overall, AA patients had a higher freaquency of mutations in
a wider array of genes suggesting increased levels of genomic
instability. JAK-Stat and HER2 signaling were unique to the AA
and PTEN and mTOR were unique to the CA profiles. Many
pathways identified by the mutational profiles were predicted
to be down-regulated by the transcript expression profiles.
Speaker Biography
Lesleyann Hawthorn recieved her Ph.D. from the University of London, UK. She
completed a postdoc at the Cleveland Clinic, OH, USA. Subsequently she obtained an
Assistant Professorship at Rosewell Park Cancer Institute, NY, USA. She was awarded
an Associate Professorship at Georgia Health Sciences University, GA, USA and is
currently a Professor at the Georgia Cancer Institute at Augusta University, GA, USA.
Her research interests include genomic analysis of solid and hematological cancers
using mutational and transcript expression analyses and she has published over 60
peer reviewed manuscripts and book chapters in the field.
e:
lhawthorn@augusta.edu