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Journal of Medical Oncology and Therapeutics | Volume: 3
July 23-25, 2018 | Moscow, Russia
12
th
World Cancer Congress
Distribution of high-risk HPV genotypes in HIV-infected women of the Moscow region
Daria Podcufarova
1
, Lebedeva NN
1,2
, Enaeva MV
3
, Isaguliants MG
1
and
Pronin AYu
2
1
N. F. Gamaleya Federal Research Center
, Russia
2
Moscow regional center for prevention and control of AIDS and infectious diseases, Russia.
3
Moscow regional perinatal center, Russia
H
IV-infection increases the incidence of squamous
intraepithelial lesions ultimately leading to cervical
cancer. This study characterized the incidence of SIL and
prevalence of high carcinogenic risk types (HR-HPV) types
in HIV-positive women in relation to their immune status.
Cervical smears of HIV-infected (n=618) and HIV-negative
(n=100) women aged 19-62 were subjected to cytological
screening (BD SurePath
TM
) and HPV16/18-specific PCR
(Abbott RealTime High-Risk HPV). Of HIV(+)- women,
31% had cervical pathology: HSIL (3%), LSIL (14%), ASC-H
(2%), ASC-US (12%). None had cervical cancer. Pathology
was not related to immune status: women with CD4-
nadir >500 and <500 cells/ul had similar frequencies of
ASC-US/ASC-H/LSIL/HSIL. Positivity for HR-HPV types was
high among women aged<30, and decreased with age as
described. The decrease was dramatic in HIV-negative
(21% in aged <30 vs 2% in aged >40 years), and milder
in HIV-infected (31% in aged <30 vs 17% in aged >40)
(p<0,05). Prevalence of HR-HPV types was higher among
HIV(+) than HIV(-)-women, specifically aged >30. HIV(+)-
women with lesions were infected with at least one HR-
HPV: HPV16 (HSIL, ASC-H) or non-HPV16 (LSIL, ASC-US).
Women with CD4-nadir <500 cells/ul had highprevalence
of HR-HPVs other than HPV16/18. Prevalence of lesions
and positivity for HPV16/18 was equal in ART-treated
and untreated. We confirm higher prevalence of HR-HPV,
specifically HPV16, in HIV-infected compared to healthy
women, not directly related to immunosuppression. In
HIV-infected women, grieve neoplasia were strongly
associated with detection of HPV16, advocating creation
of therapeutic HPV16-based vaccines for HIV-infected.
Speaker Biography
Daria Podcufarova has graduated Russian State Medical University, has a specialty
in medical biochemistry and is currently working at N. F. Gamaleya Federal Research
Center for Epidemiology & Microbiology. She is studying the diversity of HPV types in
human mucosa in norm and pathology.
e:
sentientyou@gmail.com