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Journal of Medical Oncology and Therapeutics | Volume: 3
July 23-25, 2018 | Moscow, Russia
12
th
World Cancer Congress
Tumor-on-a-chip in an integrated microfluidic platform
Shay Soker
Wake Forest School of Medicine, USA
O
rganoid and organ-on-a-chip technologies are rapidly
advancing towards deployment for drug and toxicology
screening applications. The organoids replicate native tissue
structure and function and thus are superior to traditional 2D
cultures in order to study organ development, function and drug
toxicity. We developed an assortment of bioengineered tissue
organoids and tissue constructs that are integrated in a closed
circulatory perfusion system, facilitating inter-organ responses.
We observe drug responses that depend on inter-tissue
interaction, illustrating the value of multiple tissue integration for
in vitro study of both the efficacy of and side effects associated
withcandidatedrugs.Otherapplicationsfocusondiseasessuchas
tissue fibrosis and cancer. Specifically, to study tumor growth and
drug response for future use in personalized/precision medicine
e:
ssoker@wakehealth.edu