cancer-2018-posters-abstracts

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Journal of Medical Oncology and Therapeutics | Volume: 3

July 23-25, 2018 | Moscow, Russia

World Cancer Congress

Effects of folic acid on progesterone-enhanced Breast Cancer cell proliferation and migration

Wen-Sen Lee, Hui-Chen Wang

and

Yen-Nien Huo

Taipei Medical University, Taiwan

reviously, we have demonstrated that female sex hormone

receptors and folic acid receptor form a complex and female

sex hormone can abolish the folic acid-inhibited proliferation and

migration inendothelial cells. The findings of interactionbetween

female sex hormone and folic acid led us to propose that folic

acid might interfere with the progesterone-enhanced breast

cancer cell proliferation and migration. In the present study,

we demonstrate that treatment with progesterone enhanced

proliferation and migration of breast cancer cell lines (T47D,

MCF-7 and BT474), while co-treatment with folic acid abolished

the progesterone-induced enhancement of proliferation and

migration in these breast cancer cell lines. Since we previously

showed that progesterone enhanced breast cancer cell

proliferation and migration through activating the cSrc-mediated

signaling pathway, we investigated the molecular mechanism

underlying folic acid-prevented the progesterone-enhanced

breast cancer cell proliferation and migration by examining the

effectof co-treatmentwithprogesteroneand folicacidonthecSrc

activity. Our data showed that co-treatment with folic acid and

progesterone increased the formation of p140Cap-cSrc complex,

subsequently activating Csk, which in turn phosphorylated

cSrc at Tyrosin-527, thereby causing cSrc inactivation. The

findings of this study might provide a new strategy for

preventing the progesterone-enhanced breast cancer progress