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Dermatol Res Skin Care 2017 | Volume 1 Issue 1
World
Dermatologist Summit and Skin Care Expo
October 30-31, 2017 | Toronto, Canada
Significant lightening effect of a whitening formula (AE brightening complex-01) compared to 4%
hydroxyquinone
Saadiah S
Annur Skin Specialist Clinic, Malaysia
Introduction: Fair skin complexion is much preferred by the
Asian population. Four percent hydroquinone has been known
to be effective as a whitening agent albeit unwanted effects
such as worsening pigmentation, onchronosis and irritation
have been well documented. This study aims to compare
the lightening effects and the safety profile of a novel topical
formulation derived from Vitamin C in combination with
plant’s extract, known as AE Brightening Complex- 01 with a
standard formulation containing four percent Hydroquinone.
A case control study was conducted to evaluate the efficacy of
AE Brightening Complex-01 versus 4% Hydroquinone cream in
lightening normal skin colour.
Materials & Methods: AE Brightening Complex-01 contains
refined stabilized vitamin C complex and plant’s extract
as active ingredient. All 20 subjects were applied with AE
Brightening Complex-01 on their right arm, 4% hydroquinone
on their left arm twice a day for 28 days. Their left forearm was
left untreated. Visual and colorimeter assessment of the right
arm, left arm and left forearm were done on day 0, Day 7, Day
14, Day 21 and Day 28.
Results: Skin areas treated with AE Brightening Complex-01
showed significant degree of lightening effect (+1.69) after
21 days of treatment compared to areas treated with 4%
hydroquinone (+0.47) and untreated area (+0.13). This was
tested using Skin Colorimeter Konica Minolta CR 10. There
was further improvement at day 28 of the treated area with
AE Brightening Complex-01 (+1.96), 4% hydroquinone (+0.66)
and untreated area (-0.09). The AE Brightening Complex-01
formulation showed significant skin lightening effect compared
to standard 4 % Hydroxyquinone with p<0.05.
Conclusion: The AE Brightening Complex-01 formulation is
significantly effective to lighten normal skin colour compared
to 4% Hydroquinone.
Speaker Biography
Saadiah S has completed her graduation from Royal College of Surgeons, Ireland in
1987, currently a Consultant Dermatologist (as per Malaysia National Specialist
Register) serving Damansara Specialist Hospital, Seremban Specialist Hospital and
Annur Specialist Hospital in Malaysia. She was a Consultant Dermatologist in Hospital
University Kebangsaan, Malaysia, Committee Member of the Advance Masters
Dermatology Program, which she has set up in year 2000 in University Kebangsaan
Malaysia (UKM), where she has served from year 1992 to 2003 and attained her
Postgraduate degree, Masters in Internal Medicine and further trained by the world
renowned Dermatologist, Professor Malcolm Greaves. Since then, she has supervised
and trained many young dermatologists. Being actively involved in research, apart from
many journal publications and conference presentations, she heads the dermatology
clinical laboratory research and has successfully established two MS ISO 17025
accredited laboratory, Makmal Bioserasi for research and development and testing of
healthcare products in Malaysia.
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