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Dermatol Res Skin Care 2017 | Volume 1 Issue 1
World
Dermatologist Summit and Skin Care Expo
October 30-31, 2017 | Toronto, Canada
Non - Invasive characterization of allograft dermis, skin and scar using vibrational OCT
Frederick H Silver
The State University of New Jersey, USA
P
hysicians have been palpating dermal lesions for over 100
years to assist in the diagnosis of disease. Recently, several
papers report that cancerous lesions are stiffer (harder) than
normal tissues. These events have led to over 40 years of
research attempting to develop mechanical tests that can
non-invasively and non-destructively evaluate the mechanical
properties of skin in health and disease. My lab has measured
themechanical properties of a number of extracellular matrices
including skin, decellularized dermis and chemically modified
dermis for over 30 years. The mechanical behavior of skin is
complicated by several factors including: (1) time dependence
of the behavior (viscoelasticity); non-linearity of the stress-
strain behavior; (3) ability to test tissue fragments without
mechanical slippage during testing; (4) directional dependence
of the properties along and perpendicular to Langer’s Lines;
(5) assumption that Poisson’s ratio is independent of strain;
and (6) age dependence of the stiffness of skin. All these
variablesmakemeasurement and interpretation of the stiffness
(modulus) and its dependence on deformation (strain) of skin
very complex. Recently, we reported the use of optical cohesion
tomography (OCT) in combination with vibrational analysis to
measure the stiffness of normal skin and scar tissue as well as
that of decellularized and chemically modified dermis (Shah et
al., 2016, 2016a, 2017). In this technique skin is vibrated using
a speaker that employs a low intensity sound wave generated
by a cell phone app to find the resonant frequency of skin. This
is done by measuring the frequency by OCT at which maximum
deformation of the sample occurs. The frequency at which
maximum deformation occurs is related the stiffness of a
material and tissue properties such as the density.
Speaker Biography
Frederick H. Silver is a Professor of Laboratory Medicine and Pathology at Robert
Wood Johnson Medical School, Rutgers University in Piscataway, NJ. He did his Ph.D.
in Polymer Science and Engineering at M.I.T. with Dr. Ioannis Yannas, followed by a
postdoctoral fellowship in Developmental Medicine at Mass General Hospital with
Dr. Robert L. Trelstad. Over the last 40 years, he has taught biomedical engineers
and physicians at Mass General Hospital, Boston University, Rutgers University and
University of Minnesota. His research interests include connective tissue disorders,
collagen self-assembly, tissue mechanical properties, pathobiology of implants,
mechanobiology and non-invasive assessment of disease processes. He has published
over 170 research papers and book chapters and is co-inventor on over 20 patents.
e:
fhsilverfh@yahoo.com