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allied
academies
September 20-21, 2017 | Philadelphia, USA
Global summit on
TUBERCULOSIS AND LUNG DISEASE
Int J Respir Med 2017 Volume 2 Issue 2
D
rugs designed to treat lung diseases or for systemic
absorption through the lung require optimum particle
(aerosol) size (2 to 6
μ
m) to target delivery. Current advanced
commercial ultrasonic nebulizers for pulmonary drug
delivery utilize piezoelectric disk together with an active
vibrating mesh or a passive screening mesh to produce
medicinal aerosols. These devices produce aerosols with
uncontrolled sizes and broad (polydisperse) size distributions.
Furthermore, these devices are prone to clogging due to the
mesh component of the design and overheating due to the
high drive power required which make them unsuitable for
administration of expensive medications. In this paper the
scientific and technological innovations of the patented
Faraday waves-based meshless ultrasonic nebulizers capable
of producing optimum aerosol sizes are introduced first.
Realization of a fully integrated clog-free pocket-size (14 x
6 x 3 cm
3
) nebulizer and applications to aerosolization of a
variety of common pulmonary drugs and experimental drugs
with desirable aerosol characteristics are then presented.
Speaker Biography
Chen S Tsai is a Chancellor’s Professor of the University of California at Irvine (UCI),
received his PhD in Electrical Engineering from Stanford University in 1965. He joined
Carnegie-Mellon University as Assistant Professor (1969), and was awarded Endowed
Chair Professorship (1979). He joined UCI in 1980, and served as the Founding Director
of the Institute for Applied Science and Engineering of Academia Sinica in Taiwan (1999-
2002). He published 190 journal papers, 450 conference papers, and 14 encyclopedia
and book chapters; received the 2013 IEEE UFFC Society Achievement Award
with award citation. For pioneering contributions to the science and technology of
integrated acousto-optics, ultrasonic monodisperse micro droplet generation, acoustic
microscopy, and guided-wave magneto-optics and International Micro-Optics Award.
He is Fellow Member of IEEE, OSA, AAAS, SPIE, Russian Popov Society, Academician
of Academia Sinica, and a Foreign Member of Russian Academy of Applied Sciences.
e:
cstsai@uci.eduClog-free pocket-size ultrasonic nebulizer using multiple fourier horns-driven faraday waves
Chen S Tsai
1
, S C Tsai
1
, R W Mao
1
, K Shahverdi
1
, Y Zhu
1
, M Brenner
1
, G Boss
1
, S Mahon
1
and
G Smaldone
2
1
University of California, USA
2
State Univ. of New York, USA