toxicology-recycling-2018-posters-abstracts

11 / 31

Page 52
Notes:
allied
academies
Journal of Clinical and Experimental Toxicology | Volume: 2
December 03-04, 2018 | Dubai, UAE
International Conference on
6th International Conference on
Toxicology, Clinical Toxicology & Pharmacology
Recycling & Waste Management
Joint Event
&
Embelin modulates central neurotransmitters and attenuates streptozotocin induced cognitive
impairment and biochemical abnormalities in Rats
Rimpi Arora
IFS College of Pharmacy, India
Embelin, the main active constituent of Embelia ribes, has
been reported to possess various pharmacological actions,
including anti-inflammatory, antioxidant, anticonvulsant and
neuroprotective. The present study was design to investigate
neuroprotective mechanisms and therapeutic potential of
embelin against intracerebroventricular streptozotocin (ICV-
STZ) induced experimental sporadic dementia in rats. STZ was
infused bilaterally at the dose of (3 mg/ kg/1µl/1min) ICV on
day 1st and 3rd. Spatial and non-spatial memory was evaluated
using Morris water maze and object recognition task in rats.
Embelin (2.5, 5 and 10mg/kg i.p.) was administrated for 14 days
from7thdayonwardsafter 1st ICV-STZ infusion inrats.Onday22
rats were sacrificed and hippocampal brain regions were used
to identify biochemical, neurochemical and neuroinflammatory
alterations. STZ infused rats showed significant learning and
memory deficit which was associated with increase in oxidative
stress (lipid peroxidation and nitrite), compromised antioxidant
defense (reduced glutathione), neurotransmitter alterations
(AChE, dopamine, noradrenaline, 5-hydoxytryptamine,
Gama amino butyric acid and glutamate) and elevation in
neuroinflammatory cytokine (IL-1 β, IL-6 and TNF- α) levels.
Embelin dose dependently attenuated STZ-induced cognitive
deficit and biochemical alterations and restored hippocampal
neurochemical levels. The observed protective effect might be
attributed to the antioxidant and anti-inflammatory potential of
embelin and its ability to restore hippocampal neurochemistry.
Thus, the outcomes of the current study suggest therapeutic
potential of embelin in cognitive disorders such as SAD.
Speaker Biography
Rimpi Arora pursued B pharm from SBS College of Pharmacy, Patti Punjab, (Year 2003-
2006). She pursued her M pharm from IFS College of Pharmacy, Moga Punjab (Year 2007-
2009) and her D pharm from SBS College of Pharmacy, Patti Punjab (Year 2001-2003). Her
Field of Specialization is Neuropharmacology and Neurobiology.
e:
Rimpi Arora, Toxicology 2018 & Recycling 2018, Volume 2
DOI: 10.4066/2630-4570-C1-003