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Journal of Clinical and Experimental Toxicology | Volume: 2
December 03-04, 2018 | Dubai, UAE
International Conference on
6
th
International Conference on
Toxicology, Clinical Toxicology & Pharmacology
Recycling & Waste Management
Joint Event
&
Pattern of ocular toxicity in patients on Antipsychotic Drug Therapy at Alexandria Main University
Hospital
Wafaa Mohammed Elsehly
Alexandria University, Egypt
S
chizophrenia is amental disorder characterized by abnormal
social behaviour and failure to understand what is real.
The eye is supposed to be the second organ to manifest drug
toxicity following liver. This study aimed to assess the possibility
of occurrence of ocular toxic effects of antipsychotic drugs,
evaluate intraocular pressure of chronic psychotic patients
treated with antipsychotic medications, and relate ocular toxic
effects in patients treated with a variety of antipsychotics to
duration of treatment and to detect early ocular toxic effects
for early intervention. The present study conducted on 100
chronic adult psychotic patients out of them 78% males and
22% females attending EL- HADDRA University Hospital treated
with antipsychotic drugs for a period more than six months.
In this study 70% of the patients were treated by both typical
and atypical antipsychotic drugs, 16% of them received only
atypical antipsychotics and the least percentage was on
typical antipsychotics (14%). 2% of cases show conjunctival
pigmentations whom treated with typical antipsychotics alone
4% of cases only suffered from corneal opacity, all of them
treatedwith typical antipsychotics alone. Therewas a significant
relation between lens opacity and duration of treatment
with typical antipsychotics alone. There was a significant
correlation between duration of treatment with antipsychotics
and IOP for both eyes and a significant difference between
different duration categories of treatment with antipsychotics
regarding to IOP in both eyes, it was highest with duration
more than 25 years. Most of the cases have free fundus and
only (2%) of them who treated with typical antipsychotics
alone have abnormality. So increased cup disc ratio occurs
only with typical antipsychotic. It was concluded that ocular
toxicity was manifested mainly with typical antipsychotics
that affected by duration of treatment. The incidence of
toxicity decreased with combination of typical and atypical.
Speaker Biography
Wafaa Mohammed Elsehly has completed her PhD at the age of 34 years from
Alexandria University, EGYPT. She is a Professor of Forensic Medicine and clinical
toxicology in Armed Faculty of Medicine Ministry of defense .she is the Director of
Quality Assurance Unit in Faculty of medicine Alexandria University. She has many
publications, and actively participated in many international conferences. She
contributedwritingmanybooks inforensicmedicineandtoxicology,ethics,andnursing.
She attended more than 50 workshops in different fields. She was included in the
2009 Edition of Who’s Who in the World. She is a reviewer in many scientific journals.
e:
wafaaelsehly@gmail.comWafaa Mohammed Elsehly
, Toxicology 2018 & Recycling 2018, Volume 2
DOI: 10.4066/2630-4570-C1-003