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J Clin Exp Tox 2017 | Volume 1 | Issue 2
Toxicology and Pharmacology
November 01-02, 2017 | Toronto, Canada
International Conference on
Novel toxicity related to nanomaterials? Silica nanoparticles cause pleural effusion and pericardial
effusion in workers and in rats
Yuguo Song
Capital Medical University, China
N
anomaterials introduce novel risk factors and potentially
lead to novel hazards within the workplace or through
environmental contamination. Here, we introduce our
study in the nanoexposed workers and animal experiments.
Further information on the novel toxicity related to the silica
nanoparticles was collected and the potential mechanisms
werediscussed.With the rapiddevelopment of nanotechnology
and the extensive use of nanoproducts, the potential hazards
of nanomaterials to the environment and human health were
widely concerned. Nanomaterials introduce novel risk factors
and potentially lead to novel hazards within the workplace
or through environmental contamination.
In vitro
and
in
vivo
studies show that the toxicities nanomaterials posed
include damage to lungs, heart, liver, kidney and nerve, as
well as reproductive and immune systems and they also have
carcinogenicity. Additionally, some studies reported the specific
toxicity of nanomaterials which appears due to their unique
physicochemical properties. However, it is still controversy
in regarding to the nano-specific toxicity, and some scientists
regard that there is no evidence of novel ‘nano-specific hazard’
comparing to micro –materials. We previously reported that
a group of patients exposed to nanomaterials presented
with an unusual disease with pleural and pericardial effusion,
pulmonary fibrosis and granuloma. And our further rodent
study shows that silica nanoparticles that were isolated
in patients can also cause pleural effusion and pericardial
effusion- a rare and unusual symptom- which may be the
novel toxicity related to nanomaterials. Here, we introduce
our study in the nanoexposed workers and animal experiment,
further information on the novel toxicity related to the silica
nanoparticles was collected and the potential mechanisms will
be discussed.
Speaker Biography
Yuguo Song works as a Chief-physician and the Deputy Director at the Department
of Occupational Medicine & Clinical Toxicology, Beijing Chaoyang Hospital, Capital
Medical University (Beijing, China). He received his BS degree in Clinical Medicine from
the University of Tsingdao Medical College, Shandong Province in 1990, and then he
got his MD and PhD degree in Capital Medical University. He is the recipient of several
research achievement awards including Wu Zhizhong Prize in Occupational Medicine
(China) and International Travel Award from the American Academy of Clinical
Toxicology. He worked as a Visiting Scholar in 2010 at West Virginia University, USA. His
research focus is on occupational lung disease, clinical toxicology and nanotoxicology.
e:
songrain123@hotmail.com