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J Clin Exp Tox 2017 | Volume 1 | Issue 2
Toxicology and Pharmacology
November 01-02, 2017 | Toronto, Canada
International Conference on
Functionalization of ZnO nanoparticles by 3-mercaptopropionic acid for aqueous curcumin delivery:
Synthesis, characterization and anticancer assessment
M Reza Khorramizadeh
1
, Seyed-Behnam Ghaffari
2
, Mohammad-Hossein Sarrafzadeh
2
, Zahra Fakhroueian
2
and
Shadab Shahriari
1
1
Tehran University of Medical Sciences, Iran
2
University of Tehran, Iran
I
nherent biocompatibility and stability of zinc oxide
nanoparticles (ZnO-NPs) and their biomedical potentials
make them an emerging candidate for drug delivery. The aim
of this studywas to develop and assess a simple procedure for
surface functionalization of ZnO-NPs by 3-mercaptopropionic
acid (MPA) for water-soluble curcumin delivery. Carboxyl-
terminated ZnO nanoparticles were successfully made using
ZnCl
2
and NaOH in the presence of MPA. The functional
groups were activated by 1, 1’-Carbonyldiimidazole (CDI) and
the curcumin bonding was carried out at room temperature
for 24 h. The core-shell nanocomposite had a significant
better solubility versus free curcumin, as characterized
by XRD, FTIR, UV-Vis spectrophotometry, DLS, and TEM,
p<0.005. In addition, MTT cytotoxicity assessment on MDA-
MB-231 breast cancer cells revealed a drop of IC
50
values
from 5 μg/mL to 3.3 μg/mL for free curcumin and ZnO-
MPA-curcumin complex, respectively. This result showed
an augmented cancer-inhibitory effect of nanoconjugate
complex. In conclusion, the presented improved solubility
and elevated functionality of novel ZnO-MPA-curcumin
nanoformula is promising, and could be considered for new
therapeutic endeavors.
Speaker Biography
M Reza Khorramizadeh, is a full Professor at Tehran University of Medical Sciences
(TUMS), directs Biosensor Research Center and newly instituted Zebra Fish Core Lab at
Endocrinology and Metabolic Molecular-Cellular Sciences Institute. Concurrently, he is
a 2nd affiliation to the Dept. of Medical Biotechnology, School of Advanced Technology
in Medicine, TUMS.
e:
khoramza@tums.ac.ir