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allied
academies
March 14-16, 2019 | London, UK
12
th
International Conference on
8
th
International Conference on
Vascular Dementia and Dementia
Neurological Disorders and Stroke
Joint Event
&
Journal of Brain and Neurology | Volume 3
A typical presentation of frontal temporal lobe Dementia
Ruth Akiyo Mizoguchi, Will Haskins, Jonathon Wood , Maggie Ting , Clare Anderson, Chris Carswell
and
Inaki Bovill
Chelsea and Westminster Hospital NHS foundation trust, UK
A
66-year-old Caucasian lady presented to hospital with a
first episode of seizure. She was found to be hyponatraemic
(sodium 108mmol/L ) secondary to Primary Polydipsia which
she required intensive care unit (ICU) admission. Her routine
blood tests and cerebral spinal fluid were normal. MRI brain
showed cerebral atrophy with disproportionate involvement
in medial temporal with asymmetric hippocampus, and frontal
lobes.
Post ICU admission, she continued to display impairment of
episodic memory, with anomia, mild fluent aphasia and deficits
in executive function. She also showed signs of Behavioural
Psychological symptoms of Dementia (BPSD) and displayed
hyperphagic tendencies towards sugary foods . Both donepezil
and memantine were trialled during her time on the ward but
neither provided symptomatic benefit.
At the memory clinic post discharge, her family mentioned
she had episodic memory decline over the last 4 years with an
accelerated decline 6 months prior to her hospital admission
.She also developed a compulsion in drinking up to15L of
water per day. Her neuropsychometric test included : Frontal
Assessment Battery 10/18, Frontier executive test 3/15 mainly
affecting verbal fluency and lucia fluency. She failed in both
stroop test and go-no-go test and showed signs of disinhibition
and repetitive compulsive behaviour. A diagnosis of behavioural
variant Frontal Temporal Lobe Dementia ( bvFTD) was formally
made. Memantine was stopped and trazodone was prescribed
which shown some improvement in her agitation.
Speaker Biography
Ruth Akiyo Mizoguchi is a Care of the Elderly Consultant and Dementia Lead at Chelsea
and Westminster NHS Foundation Trust (London, UK) after working at the Royal Free
NHS Foundation Trust from 2012- 2018. She is an Honorary Senior Clinical lecturer
at Imperial College where she provides dementia teaching to medical students and
doctors. She originally obtained a medical degree at Tokai University School of
Medicine, Japan and then completed further medical training at Imperial College,
London. She received her specialist training in general internal medicine and geriatric
medicine in London. During her specialist training she worked in Hong Kong for a year
where she developed interest in dementia. She also gained research experience in
Neuroimaging & Dementia at Imperial College. She visited UCSF Memory Aging Center,
USA in 2018. She set up the Multidisciplinary team Memory Clinic with Neurologists at
Chelsea and Westminster Hospital.
e:
aki_uk@yahoo.com