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academies
March 14-16, 2019 | London, UK
12
th
International Conference on
8
th
International Conference on
Vascular Dementia and Dementia
Neurological Disorders and Stroke
Joint Event
&
Journal of Brain and Neurology | Volume 3
Neuropsychiatric symptoms in AD, VaD, MCI and VCI Thai cohort at the Memory Clinic at Siriraj
Hospital, Thailand
Vorapun Senanarong
Mahidol University, Thailand
Neuropsychiatricsyndromes (NPs) play an important role in
recognizing and diagnosing specific neurocognitive disorders
(NCD). They assist in differential diagnosis among the
NCD. Specific diagnostic criteria have been developed for
psychosis in AD, depression in AD, apathy in AD and other
NDD, and agitation in cognitive disorders. Vascular cognitive
impairment (VCI) requires onset of the clinical syndrome to
be related to a cerebrovascular event and evidence of decline
in frontal executive functioning, plus one of the following:
gait disturbance, urinary symptoms, or personality and mood
changes. There must also be evidence on neuroimaging of
cerebrovascular disease (CVD).
Objectives:
We explored NPs in the memory clinic cohort at
Siriraj Hospital, Thailand. Five hundreds and two individuals
with Alzheimer disease dementia (AD), 185 with vascular
dementia (VaD), 175 with mild cognitive impairment, and 30
with vascular cognitive impairment (VCI) were screened for NPS
by using neuropsychiatric inventory (NPI). Factor analyses were
utilized to weigh neuropsychiatric domains of NPs.
Results:
The prevalence of delusion, hallucination, agitation,
apathy, irritability and aberrant motor activity were statistically
differed among AD, VaD, and MCI groups. Only the prevalence
of apathy and agitation were significantly differed between
AD and VaD. When comparing MCI and VCI, the prevalence of
night time behavior was the only NPs that significantly differed
between these 2 CI groups. Factor analysis in AD Thai cohort
foundthatNPsweredividedintopsychoticfactors,moodfactors,
frontal factors (euphoria and disinhibition) and miscellaneous
factors (apathy, aberrant motor activity, night time behavior,
and appetite change). While among VaD Thai cohort, NPs
were divided into frontal factors (agitation, disinhibition and
irritability), psychotic & mood factors, psychomotor factors
(euphoria, aberrant motor activity and night time behavior),
and miscellaneous factors (apathy and appetite change).
Discussion:
Asian population is known to have more
neurovascular burden than Caucasian population. In Thai
cohort, psychotic andmood factors were shown as in Caucasian
cohort. The frontal factor and psychomotor factors are
prominent in our study. It was shown in previous Asian study as
well. The NPs in VCI was lower than those in MCI Thai cohort.
The NPs in VCI and MCI was different in a night time behavior
incidence. However, the NIA-AA criteria for MCI due to AD do
not include reference to behavioral changes.
Speaker Biography
Vorapun Senanarong heads and is the Director of the Memory Clinic, the Ageing and
Dementia Program at Division of Neurology, Department of Medicine at Mahidol
University and promoted to Associate professorship in 2001. She also sits in the
subcommittee of the undergraduate training program and is a member of hospital
assurance of outpatient clinics of the Department of Medicine at Mahidol University.
She has published more than 40 papers in both national and international journals,
and had written chapters in books on dementia. She is actively participates in both
national and international societies.
e:
vorasenanarong@yahoo.com