stroke-vascular-dementia-2019-posters-abstracts

Page 69

allied

academies

March 14-16, 2019 | London, UK

International Conference on

Vascular Dementia and Dementia

Neurological Disorders and Stroke

Joint Event

Journal of Brain and Neurology | Volume 3

The use of Computational Fluid Dynamics in solving the mystery of origin of Cerebral Aneurysms

Bulang Gao

Henan Provincial People’s Hospital, China

o investigate the mechanisms of cerebral aneurysms and

the effect of treatment modalities on the genesis of cere-

bral aneurysms. Seven hundred and twenty four patients with

cerebral aneurysms were investigated in the locations of the

cerebral aneurysms using the angiographic data. The angio-

graphic data of 140 patients with cerebral aneurysms were

processed for computational fluid dynamics (CFD). Different

modalities including stent-assisted coiling, coiling alone, stent-

ing alone, single stenting, Y-configuration stenting, and surgical

clipping were analyzed for their effects on the mechanisms of

CFD. Results: A total of 1018 cerebral aneurysms were detect-

ed in these patients. Seven hundred and seventeen aneurysms

involved a branch, accounting for 70.4% of all the aneurysms,

with the most populous places being the intracranial internal

carotid artery (ICA) segments (23.9%), the anterior cerebral ar-

tery (17.9%), the middle cerebral artery (17.8%), and the pos-

terior circulation (9.3%). 301 aneurysms were located on a vas-

cular curve (29.6%), with the most populous site being the ICA

(25.4%), the intracranial vertebral artery (2.2%), and the distal

cerebral arteries (1.5%). Not a single aneurysm was found on a

straight segment of vessel. CFD analysis showed some common

features that, on the wall where a cerebral aneurysm was gen-

erated, two peak values and one minimal value were demon-

strated on the curve of wall shear stress while one peak value

was revealed on the total pressure curve. Conclusion: Cerebral

aneurysms are initiated at sites with both high wall shear stress

and total pressure, and stenting especially Y-shaped stenting

can decrease the hemodynamic stresses for aneurysm initia-

tion while coiling alone or surgical clipping do not. Stenting with

Y configuration is a better choice of treatment than coiling or

surgical clipping inmanaging the genesis of cerebral aneurysms.