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allied
academies
March 14-16, 2019 | London, UK
12
th
International Conference on
8
th
International Conference on
Vascular Dementia and Dementia
Neurological Disorders and Stroke
Joint Event
&
Journal of Brain and Neurology | Volume 3
Alzheimer’s disease and severe cerebral Amyloid Angiopathy; (CAA), CAA related Leukodystrophy
leading to synergistic rapidly progressive Dementia
John P Provias
Hamilton Health Sciences, Canada
W
e present an informative case of a female with a rapidly
progressive dementing illness clinically, initially thought
to represent a form of prion encephalopathy. The patient suc-
cumbed to the illness after an approximate two month course
and came to a neuro autopsy. Examination of the brain showed
no changes of prion disease, but rather typical Alzheimer’s dis-
ease neuropathology with a severe cerebral amyloid angiopa-
thy (CAA). No other significant small vessel disease such as hya-
linizing arteriosclerosis was present. The severe CAA was wide-
spread, was unassociated with infarction, but lead to a marked
generalized secondary leukodystrophy. We emphasize the in-
terrelationship of Alzheimer’s disease and CAA, in particular se-
vere CAA which can produce a vascular based leukodystrophy.
This in turn can synergize with and contribute significantly to
the dementia. This can contribute to the underlying pathogen-
esis of the dementia through a white matter disconnection syn-
drome with acceleration of progression of the Alzheimer-type
pathology. Furthermore, the accelerated clinical course due to
the synergismcanmimic other dementias such as prion disease.
e:
provijoh@hhsc.ca