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Page 51
Virology research J 2017 Vol 1 Issue 2
Notes:
July 26-27, 2017 | Vancouver, Canada
WORLD CONFERENCE ON STDs, STIs & HIV/AIDS
allied
academies
A
chieving 95% of adherence is a major problem faced
among HIV/AIDS patients at the Bafoussam Regional
Hospital. With an active file of about 4500 patients on
treatment at the centre, an average of about 300 patients
per month do not report to the pharmacy for refill of
drugs. A descriptive study was carried out at the Approved
Treatment Centre of the Bafoussam Regional Hospital to
identify the reasons why adult patients on ART did not report
to the centre for refill. The study included 304 patients who
were lost to follow-up in the month of January 2015. Firstly,
phone calls were made to contact these subjects, then an
interview with those who finally returned to the centre. The
median age group was 35-45years, 59.5% were females.
After the phone calls were made, 56% of phone numbers
were not going through; 18% (54) promised to come back;
the rest were reported either dead or did not pick up their
phone. Of the 54 subjects who promised to return, 52 were
received and interviewed; 46% (24) were resident out of
town (Bafoussam) and could not travel; 17 said they were
tired of taking ART, 8 declared to have been admitted in
another hospital, 7 were receiving traditional medicines, 7
could not afford the transport fare to the treatment centre,
3 were derailed by pastors who declared them healed; 10
other patients declared to still have medicines. Therefore,
HIV patients in Bafoussam are encouraged to receive ART in
their hometown
Cause of poor retention in care in adult HIV patients on treatment at the Bafoussam Regional Hospital,
Cameroon
Atemnkeng Francis Njukeng
Bafoussam Regional Hospital, Cameroon
I
n recent years, the unparalleled and functional properties
of essential oils have been extensively reported, but
the sensitivity of essential oils to environmental factors
and their poor aqueous solubility have limited their
applications in industries. Hence, we encapsulated CEO
in chitosan nanoparticles by an emulsion-ionic gelation
with pentasodium tripolyphosphate (TPP) and sodium
hexametaphosphte (HMP), separately, as cross-linkers. The
nanoparticles were analyzed by Fourier transform infrared
spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV-
Vis), differential scanning calorimetry (DSC), scanning
electron microscope (SEM) and dynamic light scattering
(DLS). The encapsulation efficiency (EE) and loading capacity
(LC) of CEO in chitosan nanoparticles increased with the
increase of initial CEO amount. The nanoparticles displayed
an average size of 30-80 nm with a spherical shape and
regular distribution.
In vitro
release profiles exhibited an
initial burst release and followed by a sustained CEO release
at different pH conditions. The amount of CEO release from
chitosan nanoparticles was higher in acidic pH to basic or
neutral pH, respectively. The biological properties of CEO,
before and after the encapsulation process were evaluated
by 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) and agar
disc diffusion method, respectively. The results indicated
the encapsulation of CEO in chitosan nanoparticles could be
protected the quality.
e:
akbaresmaeili@yahoo.comIn vitro release and biological activities of Carum copticum essential oil (CEO) loaded chitosan
nanoparticles
Akbar Esmaeili
and
Azadeh Asgari
Islamic Azad University, Iran