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Journal of Dermatology Research and Skin Care | Volume 2
May 14-15, 2018 | Montreal, Canada
Spring Dermatology &
Skin Care Expo Conference
P
hosphorylase kinase is an enzyme released five mins
after injury. This dual specificity enzyme phosphorylates
both serine and tyrosine moieties necessary to activate
downstream NF-kB (released 30 mins post-injury) resulting
in gene transcription of multiple injury-induced processes,
including inflammation and scarring. Curcumin, a selective
and non-competitive phosphorylase kinase inhibitor, blocks
NK-kB-dependent processes, resulting in healing of damaged
tissue (burns) with minimal scarring. Photo-damaged skin
from UVB and UVA injury is further complicated by DNA
damage, with the formation of cells with increased potential
for tumor transformation. The DNA Damage Repair (DDR)
Pathway, triggered by DSBs (double stranded breaks) is
governed at its entry by a family of phosphatidylinositol
3-kinases - ATR, ATM and DNA-PK, that control Cell
Cycle Arrest, Nucleotide Excision/Repair and DNA strand
replication respectively. Phosphorylase kinase has also been
shown to phosphorylate the phosphatidylinositol 3-kinases,
thus initiating the laborious DNA Damage Repair Pathway
that often results in survival of DNA damaged cells with
an increased risk of tumor transformation. Curcumin, by
inhibiting phosphorylase kinase, therefore, blocks the entry
into the DNA Damage Repair Pathway, resulting in Curcumin-
induced apoptosis, which not only induces early removal of
DNA damaged cells but also allows the space for replacement
by new healthy undamaged cells. This process results in
the rapid repair of burns and sunburns and decreases the
risk of survival of DNA damaged cells with increased risk
of photo-carcinogenesis. In chronically photo-damaged
skin, the removal of premalignant and early malignant cells
by Curcumin-induced apoptosis is also beneficial in the
management of photo-damaged skin. In this presentation,
we have included clinical examples of the salutary effects of
topical Curcumin in burns and photo-damaged skin.
Speaker Biography
Madalene C Y Heng is a Professor of Medicine/Dermatology, David Geffen UCLA School
of Medicine. After completion of 25 years in full-time academia, she is currently in
private practice as a Dermatologist in Camarillo, California. She is the author of over
85 publications, in peer-reviewed journals. She is a reviewer of multiple journals with
Editorial positions in others. Her expertise includes an interest in the biochemistry and
pathophysiology of disease including acne, wound healing and psoriasis. She is the
Inventor of Curcumin gel.
e:
madaleneheng@aol.comCurcumin-induced apoptosis in the repair of burns and photo-damaged skin
Madalene C Y Heng
UCLA School of Medicine, USA