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N o v e m b e r 0 5 - 0 6 , 2 0 1 8 | P h i l a d e l p h i a , U S A
3
rd
INTERNATIONAL OBESITY SUMMIT AND EXPO
&
&
DIABETES, NUTRITION, METABOLISM & MEDICARE
2
nd
International Conference on
Joint Event on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
alliedacademies.comYEARS
LASER, OPTICS AND PHOTONICS
World Conference on
Obesity Summit 2018 & Diabetes Conference 2018 & Laser Photonics Conference 2018
Biomedical Research
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ISSN: 0976-1683
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Volume 29
Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C7-020
DIABETES AND COGNITIVE BRAIN FUNCTION: IS DIABETES AN
ACCELERATED FORM OF AGEING?
Amer Kamal Al Ansari
Arabian Gulf University, Bahrain
T
he aim of the present study was to examine learning and hippocampal synaptic plasticity in ageing and diabetes. Many of the
processes which have been implicated in the pathogenesis of brain ageing are also involved in the development of diabetic
complications. We investigated Morris water maze performance and examined hippocampal synaptic plasticity ex vivo in young
adult and aged diabetic and non-diabetic rats. Rats were examined after 2 months of diabetes, which produces half-maximum
deficits in synaptic plasticity in young adult rats. Aged rats were examined at 2 years of age, when they have developed moderate
changes in synaptic plasticity due to aging alone. Significant learning impairments were observed in young adult diabetic rats
compared with controls. These impairments were even greater in aged diabetic animals. In hippocampal slices from young adult
diabetic animals, long-term potentiation was impaired compared with controls. In contrast, induced long-term depression was
enhanced in slices from diabetic rats compared with controls. It is concluded that both diabetes and ageing affect learning and
hippocampal synaptic plasticity. The cumulative deficits in learning and synaptic plasticity in aged diabetic rats indicate that the
effects of diabetes and ageing on the brain could interact. Relative fEPSP slopes after different conditioning stimuli in hippocampal
slices from young adult (Left) and aged animals (right). Diabetic animals in both groups show enhanced LTD and depressed LTP
expressions when compared to the controls. Young diabetic animals had comparable defects to the aged control group indicating
that DM acts like an accelerated ageing process.