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Biomedical Research
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Volume 29
Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C7-020
FIBROBLAST GROWTH FACTOR 21 IN PREDICTION OF CORONARY
ANGIOGRAPHY RESULT IN STABLE CORONARY ARTERY DISEASE
PATIENTS
Matej Stančík
Comenius University, Slovakia
Background:
FGF21 is adipokine affecting both glucose and lipid metabolism. Anti-apoptotic effect of FGF21 on the endothelium
was previously proved.
Methods and Results:
Transversal design performed on 203 subjects divided into subgroups based on the presence of hemody-
namically significant coronary artery stenosis and stable coronary artery disease. Mean FGF21 concentration in stable coronary
artery disease patients (323,16 ± 434,66 pg/ml) was significantly higher (t (201) = 2,082; p = 0,039; n = 203), than in healthy controls
(266,46 ± 417,13 pg/ml). Multiple regression analysis proved, that the FGF21 measurement can´t be utilized as a surogate marker
for the stable coronary artery disease. Contribution of the FGF21 measurement to the prediction of significant coronary stenosis
was quantified using the hierarchical regression. Interaction analysis was used to detect between – variable interactions. The con-
tribution of FGF21 added into the model based on known risk factors of significant coronary stenosis was small, yet statistically
significant (2(4) = 25,606; p 0,001; n = 123; Nagelkerke R2 = 0,041; OR FGF21 = 2,366). Smoking was identified as the moderator
of the direct effect between FGF21 and hemodynamically significant coronary artery stenosis. Adjusting for the moderator variable
allowed us to build a regression model, in which the contribution of the FGF21 to the prediction of significant coronary stenosis was
clinically relevant (2(3) = 30,778; n = 81; p 0,001; Nagelkerke R2 = 0,425; OR FGF21 = 7,013).
Conclusions:
FGF21 can´t be utilized as a screening marker for the stable coronary artery disease in general population. FGF21
measurement has a potential to be utilized as a predictor of diagnostic coronary angiography result in non – smoking stable cor-
onary artery disease patients. This work was supported by the SRDA (Slovak Research and Development Agency) grant: APVV –
14 – 0153, ARACS - Adipokine Regulation and Acute Coronary Syndrome in young adults.“ This work was supported by the VEGA
(The Scientific Grant Agency of the Ministry of Education of the Slovak Republic) grant: VEGA 1/0160/16 „Diagnostic - prognostic
relevance of adipocytokine network and glucose homeostasis assessment in cachexia.