obesity-congress-diabetes-congress-2018-posters

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O c t o b e r 1 5 - 1 6 , 2 0 1 8 | T o k y o , J a p a n

Obesity Congress 2018, Diabetes Congress 2018 & Vaccines Congress 2018

Biomedical Research

ISSN: 0976-1683

Volume 29

WORLD OBESITY CONGRESS

WORLD VACCINES AND IMMUNOLOGY CONGRESS

DIABETES AND ENDOCRINOLOGY

International Conference on

Joint Event on

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

alliedacademies.com

YEARS

Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C5-014

COMPARATIVE EFFECTIVENESS OF

ABELMOSCHUS ESCULENTUS

. (OKRA) AND ACARBOSE IN LOWERING BLOOD GLUCOSE: AN

EXPERIMENTAL STUDY USING STREPTOZOTOCIN-INDUCED DIABETIC

RATS

Anniline Teng, F M C De Guzman, E D V Marcelo,

S A Mohamed, S A C Ong Siu, A L P Orille,

R P D Punzalan, P S V Sawen

and

D P Wy

Manila Central University, Philippines

iabetes is presently a serious worldwide epidemic, affecting about 382 million people globally in 2013 and directly causing

the deaths of more than 1.5 million people in 2012. This study evaluates the glucose-lowering potential of

Abelmoschus es-

culentus L

. (okra) in diabetic rat models as compared to the commercial drug acarbose. In this randomized, double-blind exper-

imental study, 48 streptozotocin-induced diabetic male Sprague Dawley rats aged 75-90 days old and weighing 150-250 grams

were divided into three groups: experimental group which was given 300 mg/kg aqueous extract of

Abelmoschus esculentus L

(okra), positive control group which was given 15 mg/kg acarbose and negative control group which was given 5 mL/kg distilled

water. All groups were concurrently treated once daily orally for seven days. Blood glucose levels were measured one hour after

treatment administration using EasyTouch® glucometer. The safety of okra extract and acarbose were also determined based

on subject mortality. After seven days, the experimental group and the positive control group demonstrated glucose-lowering

effects. However, the decrease in blood glucose from the baseline up to day seven was statistically significant only in the exper-

imental group (p-value <0.05). Comparison of the glucose values among all the groups on day seven demonstrated a significant

difference in the experimental group (p value=0.02). This showed that okra extract exhibited a time-dependent effect. Also, sta-

tistical analysis of mortality which yielded a nonsignificant result established the safety of acarbose and okra extract as used in

the study. These findings prove the potential beneficial effect of

Abelmoschus esculentus L

. (okra) in the treatment of diabetes

through its glucose-lowering effect which has been exhibited to be comparable to that of the commercially prepared drug acar-

bose. Thus, it may be developed and used to treat type 2 diabetes in humans.

anniline_teng@yahoo.com