obesity-congress-diabetes-congress-2018-posters

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O c t o b e r 1 5 - 1 6 , 2 0 1 8 | T o k y o , J a p a n

Obesity Congress 2018, Diabetes Congress 2018 & Vaccines Congress 2018

Biomedical Research

ISSN: 0976-1683

Volume 29

WORLD OBESITY CONGRESS

WORLD VACCINES AND IMMUNOLOGY CONGRESS

DIABETES AND ENDOCRINOLOGY

International Conference on

Joint Event on

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C5-014

CANCER IMMUNOTHERAPY WITH USING BACTERIA

Mehrnaz Ajorloo

and

Saeed Soroush

Rudehen Azad University, Iran

Guilan University School of Medicine, Iran

ancer cells escape from the immune system this subject is nearly because the tumor is a normal body tissue that has been

out from its normal state. So, the body does not consider it as an invader. On the other hand, some cancers have evolved

in a way that they can deal with the immune system or hide from it. During recent research and studies cancer cells can be de-

tected by using a variety of bacteria to body’s defense mechanism notice their presence and attack them. Bacteria are used in

many ways in the treatment of cancer that we can point to the direct anti-tumor effects in them or transfer of effective factors.

Bacterial treatments are unique mechanisms for cancer treatment which standard methods do not have access to it. Bacteria

can specifically target tumors and actively penetrate the tissue, search and create a controlled form of infection. In this regard,

the important point is the ability to determine the location of bacterial colonies in clinical terms and possibility of diagnosis

of ambiguous tumors and metastasis by the agents. For example, Diphthera toxin (DT) is attached to the surface of the cells

expressing the precursor of HB-EGF and through endocytosis intermediate clattering enter and under a few changes after trans-

lation catalytically active and finally by inhibiting protein synthesis, cell lysis and apoptosis induction is effective in treating the

mass of cancer cells with this method.