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Insights Nutr Metab 2017
Volume 1 Issue 3 Nutrition World 2017
Notes:
Page 60
September 11-12, 2017 Edinburgh, Scotland
15 th World Congress on
Advances in Nutrition, Food Science & Technology
Role of aged crushed Allium Sativum L. on
systemic inflammatory markers in patients
with Syndrome-X
Prema Ram Choudhary and Rameshchandra D Jani
C U Shah medical college, India
Syndrome-X (Metabolic syndrome) comprised a
cluster of risk factors described by abdominal obesity,
hypertension, atherogenic dyslipidemia, hyperglycemia,
prothrombotic and proinflammatory conditions. Raw
Allium sativum L (garlic) homogenate has been explained
to diminished cardiovascular risk factors in animal model;
however, no specific studies have been conducted to
appraise the role of aged crushed Allium sativum L. on
components and inflammatory markers in syndrome-X.
Hence present study was intended to explore the role of
aged crushed garlic on systemic inflammatory markers
in patients with syndrome-X. A total of 40 patients with
syndrome-X were enrolled from diabetic’s centre of
Medical College Bikaner, India. They were endure
treatment with 100 mg/kg body weight aged crushed
garlic two times a day with usual diet for four weeks
and their anthropometric as well as serum biochemical
variables were measured both at the beginning and
end of the study. Homeostasis model assessment for
insulin resistance (HOMA-IR) was calculated. Statistical
analysis was done using IBM: SPSS version 20, and
student paired-t test was used to compare variables
before and end of treatment of aged garlic preparation.
Aged crushed garlic significantly abridged variables of
syndrome-X including waist circumference (p<0.05),
systolic and diastolic blood pressure (p<0.001), serum
triglycerides (p<0.01), fasting blood glucose (p<0.0001),
tissue narcosis factor-α (TNF-α) (p<0.05), serum leptin
(p<0.01), interleukin-6 (IL-6) (p<0.001), high sensitivity
C-reactive proteins (hs-CRP) (p<0.01) and Homoeostatic
model of insulin resistance (HOMA-IR) (p<0.001) whereas
significantly increased serum high density lipoprotein
cholesterol (p<0.0001) and adiponectin levels (p<0.01)
Moreover, there was no significant difference found in
body mass index (p>0.05) of patients with syndrome-X
after consumption of age crushed garlic for 4 weeks.
Age crushed garlic has valuable effects on systemic
inflammatory markers in patients with syndrome-X thus it
can be used as a supplementary remedy for prevention
and treatment cardiovascular disorders in patients with
metabolic syndrome.
Biography
Prema Ram Choudhary is an assistant professor in the Department of
Physiology at C. U. Shah Medical College, Gujarat, India and he is interested in
the fields of haematology, herbal medicine, metabolic syndrome, endocrinology,
cardio-respiratory physiology, and metabolism and endocrinology. Moreover,
published more than 35 original research publications in international journal
with high impact factor. He has completed his Masters in Medical Physiology
from 2001-2004 at Dr. S.N. Medical College, Jodhpur, India and in Biology
from 1996 – 1999 at Govt College Sirohi, India.
Prema Ram Choudhary et al., Insights Nutr Metab 2017