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Insights Nutr Metab 2017
Volume 1 Issue 3
Nutrition World 2017
Page 79
September 11-12, 2017 Edinburgh, Scotland
15
th
World Congress on
Advances in Nutrition, Food Science & Technology
Insights Nutr Metab 2017
Improvements in long term weight-loss
and clinical parameters with the use of
nutrigenetics in a 2-years prospective study
Maria Vranceanu
Eurogenetica, Italy
Objectives:
Genetic variation is known may influence
dietary requirements, giving rise to the new field of
nutritional genomics and raising the possibility of
individualizing nutritional intake for optimal health,
disease prevention and better weight management on the
basis of an individual’s genome This study investigated
whether the inclusion of genetic information to personalize
a patient’s diet (nutrigenetics) could improve long term
weight management.
Methods:
Two groups of patients attending a weight
management clinic were prospectively studied. The
ketogenic group consisted of 53 patients followed for
24 weeks a ketogenic diet plan with 1600 kcal. The
nutrigenetics group consisted of 61 patients were offered
a nutrigenetic test screening 26 variants in 24 genes
involved inmetabolism. This group followed a personalized
diet with 1600 kcal too and all recommendations based on
their DNA. Weight, BMI, total cholesterol, HDL cholesterol
and fasting blood sugar levels were monitored.
Results:
Both diets group performed well over the 24
weeks but after 2 years the nutrigenetic group fared better
on the clinical values of plasma glucose, total cholesterol
and HDL. Furthermore after 2 years 75%of the nutrigenetic
patients had maintained weight loss compared to 21% in
the non-genetic group.
Conclusions:
Addition of nutrigenetically tailored diets in
the weight loss phase and the general healthy eating for
life phase resulted in better longer-term BMI reduction and
improvements in blood glucose and cholesterol levels
marievranceanu@gmail.com